METHOD OF GENETICAL VARIABILITY DETECTION IN ANIMAL CELL CULTURE OF DIFFERENT PASSAGE RATE Russian patent published in 2010 - IPC C12Q1/68 

Abstract RU 2392330 C2

FIELD: medicine.

SUBSTANCE: invention can be used for genomic changes detection in cell lines of mammals, occurring within cell cultures passages number expansion, necessary for augmentation of materials for medical purposes. Test-system is based on RAPD-PCR analysis of RNA. Method was used for control of human tissue stromal cells and human fibroblast cultures of different cultivation continuance.

EFFECT: invention allows highly sensible control of genome's stability in cell cultures of different cultivation continuance.

4 cl, 6 dwg, 1 tbl, 2 ex

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RU 2 392 330 C2

Authors

Sukhikh Gennadij Tikhonovich

Pavlova Galina Valerievna

Ryskov Aleksej Petrovich

Butovskaja Polina Ruslanovna

Martirosjan Irena Ashotovna

Dates

2010-06-20Published

2008-04-16Filed