FIELD: medicine.
SUBSTANCE: claimed is method of determining DNA-hydrolysing activity of molecules and device for its realisation. Method includes adsorption of reaction mixture, which contains DNA and tested substances, on working electrode, modified with carbon nanomaterials. After that, registered and compared are values of DNA oxidation in composition of reaction mixture before standing reaction mixture (control) and after standing reaction mixture (experiment). Increase of DNA oxidation signal testifies to presence of DNA-hydrolysing activity in tested molecule.
EFFECT: invention makes it possible to simplify and reduce terms of determining DNA-hydrolysing activity of molecules, increase selectivity and sensitivity of the test reducing its cost.
8 cl, 6 dwg, 2 ex
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Authors
Dates
2011-03-10—Published
2008-09-15—Filed