MALEATE SALTS OF QUINAZOLINE DERIVATIVE EFFECTIVE AS ANTIANGIOGENIC AGENT Russian patent published in 2011 - IPC C07D403/12 A61K31/517 A61P35/00 

Abstract RU 2425043 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to a new maleate salt of 4-((4-fluorine-2-methyl-1H-indole-5-yl)oxy)-6-methoxy-7-(3-(pyrrolidine-1-yl)propoxy)quinazoline in a crystalline form A or B which exhibit the improved use properties, particularly shows higher stability. The invention also concerns versions of methods of producing the maleate salt of 4-((4-fluorine-2-methyl-1H-indole-5-yl)oxy)-6-methoxy-7-(3-(pyrrolidine-1-yl)propoxy)quinazoline in the crystalline form A or B, to a pharmaceutical composition containing them and to an application for preparing a drug used for producing an anticancer effect.

EFFECT: preparation of the compounds to be used for producing an antiangiogenic action and/or reducing a vascular permeability.

14 cl, 3 ex, 5 tbl, 10 dwg

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RU 2 425 043 C2

Authors

Makkejb Dzhejms

Dates

2011-07-27Published

2004-12-18Filed