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2 453 000

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IPC

G09B23/28(2006-01-01)

A61K31/195(2006-01-01)

A61P15/06(2006-01-01)

A61P9/08(2006-01-01)

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Application

2010144193/14, 2010-10-28

(24)

Start date

2010-10-28

(22)

Actual filing date

2010-10-28

(45)

Published

2012-06-10

(72)

Inventor

Pokrovskij Mikhail VladimirovichGureev Vladimir VladimirovichPokrovskaja Tat'Jana Grigor'EvnaPoljanskaja Oksana SergeevnaGureeva Elena GennadievnaKorokin Mikhail ViktorovichGudyrev Oleg SergeevichBelous Aleksandr SergeevichTsybul'Skij Igor' Valer'EvichDanilenko Ljudmila MikhajlovnaNovikov Oleg OlegovichTsepeleva Svetlana AleksandrovnaKotel'Nikova Lilija ViktorovnaDenisjuk Tat'Jana AlekseevnaLosenok Polina IgorevnaStupakova Elena Gennad'Evna

(73)

Holder

Gosudarstvennoe Obrazovatel'Noe Uchrezhdenie Vysshego Professional'Nogo Obrazovanija Gosudarstvennyj Meditsinskij Universitet Federal'Nogo Agentstva Po Zdravookhraneniju I Sotsial'Nomu Razvitiju"

METHOD FOR PLACENTAL MICROCIRCULATION DISORDER CORRECTION IN ADMA-LIKE GESTOSIS MODEL Russian patent published in 2012 - IPC G09B23/28 A61K31/195 A61P15/06 A61P9/08

Abstract RU 2453000 C1

FIELD: medicine.

SUBSTANCE: method involves simulating gestosis in Wistar rats by the daily intraperitoneal introduction of L-nitro-arginine-methyl ester 25 mg/kg for 14th to 20th day of pregnancy. Gestosis is corrected by using the daily intragastric introductions of L-norvaline 10 mg/kg once a day with underlying simulation for 7 days.

EFFECT: method provides manifested correction of placental microcirculation disorder ensured by increasing L-arginine availability for NO synthesis.

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RU 2 453 000 C1

Authors

Pokrovskij Mikhail Vladimirovich

Gureev Vladimir Vladimirovich

Pokrovskaja Tat'Jana Grigor'Evna

Poljanskaja Oksana Sergeevna

Gureeva Elena Gennadievna

Korokin Mikhail Viktorovich

Gudyrev Oleg Sergeevich

Belous Aleksandr Sergeevich

Tsybul'Skij Igor' Valer'Evich

Danilenko Ljudmila Mikhajlovna

Novikov Oleg Olegovich

Tsepeleva Svetlana Aleksandrovna

Kotel'Nikova Lilija Viktorovna

Denisjuk Tat'Jana Alekseevna

Losenok Polina Igorevna

Stupakova Elena Gennad'Evna

Dates

2012-06-10—Published

2010-10-28—Filed