ASYMMETRIC CATALYTIC REDUCTION OF OXCARBAZEPINE Russian patent published in 2012 - IPC C07D223/22 

FIELD: chemistry.

SUBSTANCE: described is a method of producing (S)-(+)-10,11-dihydro-10-hydroxy-5H-dibenz/b,f/azepine-5-carboxamide or R)-(-)-10,11- dihydro-10-hydroxy-5H-dibenz/b,f/azepine-5-carboxamide by reducing oxcarbazepine in the presence of a catalyst and a hydride source. The catalyst is based on a combination of [RuX₂(L)]₂, where X is chlorine, bromine or iodine, and L is an acrylic or arylaliphatic ligand, and a ligand of formula

or formula , where values of radicals are given in the claim. The hydride source is either NR³R⁴R⁵ and formic acid or [R³R⁴R⁵NH][OOCH] and, optionally, formic acid, or [M][OOCH)₈ and formic acid, where R³, R⁴ and R⁵ denote C_1-6-alkyl; M denotes an alkali metal or alkali-earth metal and x equals 1 or 2. During the process, pH is kept between 6.5 and 8. The solvent in which reduction takes place contains at least one polar aprotic solvent.

EFFECT: efficient method of obtaining the compounds.

30 cl, 4 ex, 5 tbl