FIELD: organic chemistry, chemical technology.
SUBSTANCE: invention relates a method for synthesis of (S)-(+)- and/or (R)-(-)-isomers of 10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide. Method involves separation of the corresponding racemic compound using tartaric acid anhydride. Also, invention relates to methods for synthesis of corresponding 10-acetoxy-derivatives and novel compounds of formulae (V): 
and (VI): 
wherein R means (C1-C6)-alkyl.
EFFECT: improved method of synthesis.
16 cl, 3 ex
| Title |
Year |
Author |
Number |
| METHOD OF CONVERTING (S)-(+)-I (R)-(-)-10,11-DIHYDRO-10-HYDROXY-5H-DIBENZ/b,f/AZEPIN-5-CARBOXAMIDE AND OPTICALLY ENRICHED MIXTURES THEREOF |
2005 |
- Lermont Dehvid Aleksander
- Vajngertner Gjunter
- Kremer Mattias
|
RU2382772C2 |
| METHOD OF RACEMATION OF (S)-(+) AND (R)-(-)-10,11-DIHYDRO-10-HYDROXY-5H-DEBENZ(b,f)AZEPIN-5-CARBOXAMIDE AND THEIR OPTICALLY ENRICHED MIXTURES |
2004 |
- Lermont Dehvid Aleksander
|
RU2345986C2 |
| NEW DERIVATIVES OF 10,11-DIHYDRO-10-OXO-5H-DIBENZO- -[B,F]AZEPINE-5- CARBOXAMIDE, METHODS OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION, METHOD OF TREATMENT OF CONVULSANT STATES |
1997 |
- Benesh Jan
- Soares Da Silva Patrisio Manuehl V'Ejra Arauzho
- Learmont David Aleksandr
|
RU2187503C2 |
| ASYMMETRIC CATALYTIC REDUCTION OF OXCARBAZEPINE |
2006 |
- Lermont Dehvid Aleksander
- Grasa Gabr'Ela Aleksandra
- Tsanotti-Dzheroza Antonio
|
RU2439060C2 |
| METHOD OF PRODUCING 10,11-DIHYDRO-10-HYDROXY-5H-DIBENZ/b, f/AZEPINE-5-CARBOXAMIDE |
2006 |
- Lermont Dehvid Aleksander
- Vajngertner Gjunter
- Kremer Mattias
|
RU2418789C2 |
| METHOD FOR PREPARING 10,11-DIHYDRO-10-OXO-5N-DIBENZ(b,f)AZEPINE-5-CARBOXAMIDE |
2007 |
- Lermont Dehvid Aleksander
|
RU2449992C2 |
| SUBSTITUTED DIHYDRODIBENZO[B,F]AZEPINES, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION SHOWING ANTIEPILEPTIC ACTIVITY |
1996 |
- Zhan Benes
- Patrisio Manuehl V'Ejru Arauzho Suarish Da Silva
|
RU2168502C2 |
| METHOD FOR PREPARING 10,11-DIHYDRO-1-HYDROXY-5H-DIBENZ[b,f]AXEPINE-5-CARBOXAMIDE AND 10,11-DIHYDRO-10-OXO-5H-DIBENZ[b,f]AZEPINE-5-CARBOXAMIDE |
2002 |
- Lermont Dehvid Aleksander
|
RU2311411C2 |
| N-SUBSTITUTED AZAHETEROCYCLIC CARBOXYLIC ACIDS AND THEIR ESTERS, METHOD FOR THEIR PREPARING, PHARMACEUTICAL COMPOSITION, METHOD FOR INHIBITION OF NEUROGENOUS PAIN, INFLAMMATION AND BLOOD GLUCOSE LEVEL IN PATIENT |
1996 |
- Florentsio Zaragossa Dervall'
- Knud Ehrik Andersen
- Peter Madsen
- Tine Krokh Jorgensen
- Rol'F Khol'Vaj
- Khenrik Sune Andersen
- Svenn Treppendal'
- Uffe Bang Ol'Sen
- Zdenek Polivka
- Aleksandra Silgankova
- Karel Sindelar
|
RU2244713C2 |
| APPLICATION OF 10-HYDROXY-10,11-DIHYDROCARBAMAZEPINE DERIVATIVES FOR TREATMENT OF AFFECTIVE DISORDERS |
2004 |
- Martenii Ferents
- Shmutts Markus
- Tsekhner Shtefani
|
RU2367440C2 |
