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2 443 680

(13)

(51)

IPC

C07C233/06(2006-01-01)

C07C231/06(2006-01-01)

(21) (22)

Application

2010122561/04, 2010-06-02

(24)

Start date

2010-06-02

(22)

Actual filing date

2010-06-02

(45)

Published

2012-02-27

(72)

Inventor

Dzhemilev Usein MemetovichKhusnutdinov Ravil IsmagilovichShchadneva Nina AlekseevnaKhisamova Lilija Fagimovna

(73)

Holder

Uchrezhdenie Rossijskoj Akademii Nauk Institut Neftekhimii I Kataliza Ran

METHOD OF PRODUCING N-(1-ADAMANTYL)ACETAMIDE Russian patent published in 2012 - IPC C07C233/06 C07C231/06

Abstract RU 2443680 C2

FIELD: chemistry.

SUBSTANCE: invention relates to organic chemistry and specifically to a novel method of producing N-(1-adamantyl)acetamide , used to produce pharmaceutical preparations, involving reaction of 1-bromoadamantane with acetonitrile in the presence of water under the action of manganese-containing catalysts such as MnCl₂, MnBr₂, Mn(OAc)₂, Mn(acac)₂, Mn(acac)₃, Mn₂(CO)₁₀ at temperature 100-130°C for 1-3 hours, with molar ratio [1-bromoadamantane] : [CH₃CN] : [H₂O] : [catalyst] equal to 100:300-500:100:3.

EFFECT: complete conversion of 1-bromoadamantane and absence of by-products.

2 cl, 11 ex, 1 tbl

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RU 2 443 680 C2

Authors

Dzhemilev Usein Memetovich

Khusnutdinov Ravil Ismagilovich

Shchadneva Nina Alekseevna

Khisamova Lilija Fagimovna

Dates

2012-02-27—Published

2010-06-02—Filed