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2 576 312

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IPC

C07C233/06(2006-01-01)

C07C231/08(2006-01-01)

(21) (22)

Application

2014136296/04, 2014-09-05

(24)

Start date

2014-09-05

(22)

Actual filing date

2014-09-05

(45)

Published

2016-02-27

(72)

Inventor

Dzhemilev Usein MemetovichKhusnutdinov Ravil IsmagilovichShchadneva Nina AlekseevnaKhisamova Lilija Fagimovna

(73)

Holder

Federal'Noe Gosudarstvennoe Bjudzhetnoe Uchrezhdenie Nauki Institut Neftekhimii I Kataliza Rossijskoj Akademii Nauk

METHOD OF PRODUCING N-(1-ADAMANTYL)ACETAMIDE Russian patent published in 2016 - IPC C07C233/06 C07C231/08

Abstract RU 2576312 C1

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing N-(1-adamantyl)acetamide, which is a precursor of biologically active amines, having antibacterial and antiviral activity and used for treating and preventing influenza, herpes, pneumonia etc. Method is realised by reacting 1-bromoadamantane with acetic acid amine using a catalyst in a form of manganiferous compounds, such as MnCl₂, MnBr₂, Mn(OAc)₂, Mn(acac)₃, Mn₂(CO)₁₀. Reaction is carried out at temperature of 120-130°C during 2-3 hours, with molar ratio [1-bromadamantan]: [acetamide]: [catalyst] = 100:150÷200:1÷3.

EFFECT: simple technique of producing N-(1-adamantyl)acetamide and low cost due to use of cheap catalyst in a small amount.

1 cl, 1 tbl, 1 ex

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RU 2 576 312 C1

Authors

Dzhemilev Usein Memetovich

Khusnutdinov Ravil Ismagilovich

Shchadneva Nina Alekseevna

Khisamova Lilija Fagimovna

Dates

2016-02-27—Published

2014-09-05—Filed