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2 575 213

(13)

(51)

IPC

C07C233/06(2006-01-01)

C07C231/08(2006-01-01)

(21) (22)

Application

2014136297/04, 2014-09-05

(24)

Start date

2014-09-05

(22)

Actual filing date

2014-09-05

(45)

Published

2016-02-20

(72)

Inventor

Dzhemilev Usein MemetovichKhusnutdinov Ravil IsmagilovichShchadneva Nina AlekseevnaKhisamova Lilija Fagimovna

(73)

Holder

Federal'Noe Gosudarstvennoe Bjudzhetnoe Uchrezhdenie Nauki Institut Neftekhimii I Kataliza Rossijskoj Akademii Nauk

METHOD FOR OBTAINING 1-FORMAMIDOADAMANTANE Russian patent published in 2016 - IPC C07C233/06 C07C231/08

Abstract RU 2575213 C1

FIELD: chemistry.

SUBSTANCE: invention relates to a method for obtaining 1-formamidoadamantane, which is applied in the synthesis of a number of substituted adamantanes, possessing biological activity, and serves as an initial raw material for obtaining medications, used for the treatment and prevention of flue, pneumonia, herpes, etc. The method for obtaining 1- formamidoadamantane is realised by the interaction of 1-bromoadamantane with formamide in the presence of a catalyst. As the catalysts applied are Mn-containing compounds, selected from the group MnCl₂, MnBr₂, Mn(OAc)₂, Mn(acac)₃, Mn₂(CO)₁₀ at 120-130°C for 2-3 hours with the molar ratio [1- bromoadamantane]:[formamide]:[catalyst] = 100:200÷300:1÷3.

EFFECT: simplification of the technology of 1- formamidoadamantane obtaining, reduction of the production cost due to the application of a cheap catalyst in a small amount.

1 tbl, 12 ex

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RU 2 575 213 C1

Authors

Dzhemilev Usein Memetovich

Khusnutdinov Ravil Ismagilovich

Shchadneva Nina Alekseevna

Khisamova Lilija Fagimovna

Dates

2016-02-20—Published

2014-09-05—Filed