METHOD FOR PREDICTION OF SEVERITY OF CLINICAL COURSE IN PATIENTS WITH LEPTOSPIROSIS Russian patent published in 2012 - IPC G01N33/00 G01N33/48 

FIELD: medicine.

SUBSTANCE: at the moment of admission to hospital, a patient is examined for the presence of acute renal failure, hemorrhagic syndrome, meningitis, jaundice, myocarditis, leucocytosis that is followed by calculation of linear discriminant functions by formula: "ЛДФ1"=-34.12+7.98*X1+7.95*X2+4.27*X3+6.66*X4+12.76X5+0.39*X6 "ЛДФ2"=-57.45+13.77*X1+10.86*X2+5.26*X3+8.88*X4+14.18*X5+0.45*X6, wherein X1=1 in the presence of renal failure, X1=2 in the absence thereof; X2=1 in the presence of hemorrhagic syndrome, X2=2 in the absence thereof; X3=1 in the presence of meningitis, X3=2 in the absence thereof; X4=1 in the presence of jaundice, X4-2 in the absence thereof; X5=1 in the presence of myocarditis, X5=2 in the absence thereof; X6=1 in the presence of leucocytosis, X6=2 in the absence thereof. Observing "ЛДФ1">"ЛДФ2" enables predicting severe leptospirosis, while "ЛДФ1"<"ЛДФ2" shows moderate severity.

EFFECT: use of the method enables higher prediction accuracy of the clinical course of the disease and its objectivity that provides specifying differentiated approaches to therapy of leptospirosis, improving a therapeutic effect.

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