4-AMINO-3-ARYLAMINO-6-ARYLPYRAZOLO[3,4-d]PYRIMIDINE DERIVATIVES, METHODS FOR PREPARING AND APPLYING THEM AS ANTIVIRAL AGENTS Russian patent published in 2012 - IPC C07D487/04 A61K31/519 A61P31/12 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to 4-amino-3-arylamino-6-arylpyrazolol[3.4-d]-pyrimidine derivatives showing antiviral activity. In formula I: the groups A and B independently represent phenyl, naphthyl, pyridyl, quinolyl, pyrazinyl, pyrimidyl, pyrazolyl, triazinyl, imidazolyl, furanyl, thienyl, and in each of these groups one to three hydrogen atoms can be independently substituted by the radical R¹; R¹ can be NO₂, CN, CONR² ₂, COOR², CHO, CONH₂, halogen, saturated or unsaturated, linear or branched alkyl with a number of atoms in the chain 1 to 7, saturated or unsaturated, linear or branched alkanole with a number of atoms in the chain 1 to 8, OR², SR², NR² ₂, SO₂NR³ ₂, di- or trifluoromethyl, phenyl; R² represents hydrogen, CF₃, and linear or branched alkyl with a number of atoms in the chain 1 to 7; the radical R³ represents H, benzyl, or linear or branched alkyl with a number of atoms in the chain 1 to 7; the radicals R⁴ and R⁵ represent hydrogen.

EFFECT: developing the method for preparing the compound of formula (I) and applying the compounds of the present invention as a biological agent exhibiting antiviral activity, eg for treating picornavirus infections.

9 cl, 6 ex, 1 dwg