QUINOLINE DERIVATIVES FOR TREATING INFLAMMATORY DISEASES Russian patent published in 2012 - IPC C07D401/04 C07D403/04 A61K31/4709 A61P29/00 C07C215/42 C07D215/18 

FIELD: chemistry.

SUBSTANCE: invention relates to novel quinoline derivatives of formula or pharmaceutically acceptable salts thereof, where n equals 0 or 1; when n equals 0, then R¹ is hydrogen or methyl, R² is hydroxyl, and R³ is hydrogen; and when n equals 1, R¹ is hydrogen, and one of R² and R³ is hydroxyl, and the other of R² and R³ is hydrogen. The invention also relates to specific compounds of formula (I) and a method of producing compounds of formula (I).

EFFECT: novel quinoline derivatives are obtained, having high P2X₇ antagonist activity.

9 cl, 1 tbl, 5 ex