METHOD OF PREDICTING RISK OF FORMATION OF COLD AIRWAY HYPERREACTIVITY IN PEOPLE WITH BRONCHIAL ASTHMA Russian patent published in 2013 - IPC A61B5/87 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to pulmonology, and can be applied for predicting risk of formation of cold airway hyperreactivity (CAH) in patients with bronchial asthma. For this purpose DNA is genotyped by polymorphic locus Argl6Gly of gene ADRB2 (rs 1042713) by means of method of polymerase chain reaction. After that, volume of forced exhalation for the first second (VFE1) before and 15 minutes after inhalation of two doses of fenoterol hydrobromide is determined. The results of the test are used to determine change of volume of forced exhalation for the first second in % of the proper value. In addition, fact of intake of inhalation glucocortocoids for the previous 12 weeks is made more exact. Importance of each parameter is expressed in points. After that, risk (F) and probability (P) of CAH formation are calculated by certain mathematical formulas. After that, obtained probability is compared with boundary value. If P value is higher than 0.3, increased risk of CAH formation is predicted.

EFFECT: method ensures accuracy of prediction of CAH formation in patient with BA and makes it possible to start pathogenically conditioned therapy in due time in case of necessity.

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