METHOD OF PREDICTING THE RISK OF A CLINICALLY SIGNIFICANT DECREASE IN ASTHMA CONTROL DURING A SEASON WITH HIGH AIR HUMIDITY Russian patent published in 2023 - IPC G01N33/58 C12Q1/6806 C12Q1/6827 C12Q1/686 C12Q1/6876 C12Q1/6883 A61B5/91 G16H50/30 

FIELD: medicine; pulmonology.

SUBSTANCE: invention can be used to predict the risk of a clinically significant decrease in the control of bronchial asthma (BA) with the onset of a warm season with a relative humidity of 70% or more. In the warm season of the year with a relative air humidity of less than 70%, single nucleotide polymorphisms rs1964676 of the AQP5 gene and rs3825394 of the TRPV4 gene are genotyped. The value of the Tiffno index (IT), peak volumetric velocity (PIC) and maximum volumetric velocity are spirometrically measured at the level of 50% of the forced vital capacity of the lungs (MOS50) and expressed as% of the due value. The result of assessment of BA control according to the Asthma Control Test (ACT) questionnaire is taken into account. The value of F is calculated by the following formula (1): F = 14.32655 + 1.68496× rs3825394 + 1.66128× rs1964676 - 0.19574× IT - 0.06516× POS + 0.08036× MOS50 + 0.2803× ACT. The probability of risk of a clinically significant decrease in disease control is calculated by the following formula: P=1/(1+е^-F), where F is the value obtained by calculation by formula (1). At P>0.87 a high risk of a decrease in asthma control by 5 or more points from the baseline according to the ACT questionnaire with the onset of a warm season with a relative humidity of 70% or more is predicted. At P≤0.87 a low risk of a decrease in asthma control by 5 or more points from the baseline according to the ACT questionnaire with the onset of a warm season with a relative humidity of 70% or more is predicted.

EFFECT: method makes it possible to predict a clinically significant decrease in BA control with an increase in relative air humidity in the warm season by using an original calculation formula that takes into account genotyping data, parameters of lung ventilation function and the initial level of BA control according to the ACT questionnaire.

1 cl, 3 ex