METHOD OF PRODUCING SUBSTITUTED QUINOLINES Russian patent published in 2014 - IPC C07D215/04 C07D215/18 

FIELD: chemistry.

SUBSTANCE: described is an improved method of producing substituted quinolines of general formula , where X=H, o(m, p)-CH₃, o-C₂H₅, p-OCH₃, o(m, p)-Cl, 3,4-(Cl)_2, R = H, CH₃ or C₂H₅, by reacting substituted anilines of formula XC₆H₄NH₂, where X assumes values given above, with an alcohol RCH₂CH₂OH, where R assumes values given above, and CCl₄ in the presence of a catalyst FeCl₃ ^·6H₂O with molar ratio [catalyst]:[aniline]:[CCl₄]:[RCH₂CH₂OH]=1:100:100:200, at 140°C for 2 hours; the obtained reaction mass is neutralised; the organic layer is extracted with CH₂Cl₂, filtered and the solvent is distilled; FeCl₃·6H₂O, CCl₄, RCH₂CH₂OH, taken in ratio of 1:100:200, are added to the separated residue and the second reaction step is carried out at 140°C for 2 hours. Output of substituted quinolines is 11-94%.

EFFECT: low cost of the end product owing to use of readily available reactants and catalyst.

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