FIELD: medicine.
SUBSTANCE: invention refers to medicine. A method for prediction of a risk of fractures consists in DNA recovery from peripheral venous blood leukocytes, by polymerase chain reaction with fluorescent detection, 3 polymorphic variants -1997G>T (g.3011T>G, rs1107946), -1663IndelT (g.3344_3345delTT, rs2412298) and +1245G>T (c.104-441G>T (rs1800012) found in a regulatory site of COLIA1 gene are genotyped. If having a combination of genotypes identified: 1997∗G∗T/-1663∗I∗D/ +1245∗G∗T, a category of individuals with a high risk of fractures is predicted.
EFFECT: using the declared method enables deriving criteria for evaluation of a risk of fractures with high prognostic significance.
1 tbl, 3 ex
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