METHOD FOR SKIN RESTORATION IN PATIENTS WITH VAST WOUNDS WITH SOFT TISSUE DEFECTS (VERSIONS) Russian patent published in 2014 - IPC A61B17/00 A61K35/12 A61K35/36 A61P17/02 

FIELD: medicine.

SUBSTANCE: waste skin is incised on the periphery of the wound. The incised skin is prepared from the residual subcutaneous fat and milled to fragments having an area of 1-2 mm². A dermal matrix made of dead donor's tissue is simulated after the wound shape. The dermal matrix (DM) is perforated to create traumatic discharge outflow tracts and laid on a wound bed so that to form a diastasis between perforation edges. Patient's waste skin fragments are introduced into the perforations in a staggered order. The wound is closed with a sterile gauze dressing. The other invention is allogenic mesenchymal multipotent stromal cell (MMSC) transplantation onto the wound bed in the form of the suspension by means of injections at a depth of 0.1-0.3 mm at a rate of 10 injections per 1 cm². A volume of each injection makes 0.05-0.1 ml. The dermal matrix made of dead donor's tissue is simulated after the wound shape. That is perforated to form the traumatic discharge outflow tracts and laid on the wound bed. The wound is closed with the sterile gauze dressing. The effect is ensured by using the DM as an optimum biocompatible cell carrier and creating a required micromedium in the wound, stimulating the regeneration processes ensured by a combination with the homogenised autologous skin or allogenic MMSC injections into the wound.

EFFECT: inventions provide optimising skin and soft tissue wound healing ensured by stimulating the regeneration processes by means of stromal cells, including allo- and auto-MMSC and resident stem cells.

5 cl, 2 ex