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2 535 153

(13)

(51)

IPC

A61K39/145(2006-01-01)

A61P31/16(2006-01-01)

C12N7/02(2006-01-01)

(21) (22)

Application

2013140659/15, 2013-09-04

(24)

Start date

2013-09-04

(22)

Actual filing date

2013-09-04

(45)

Published

2014-12-10

(72)

Inventor

Trukhin Viktor PavlovichPetrovskij Stanislav ViktorovichIvanova Natal'Ja Evgen'EvnaLobzin Jurij Vladimirovich

(73)

Holder

Federal'Noe Gosudarstvennoe Unitarnoe Predprijatie Nauchno-Issledovatel'Skij Institut Vaktsin I Syvorotok I Predprijatie Po Proizvodstvu Bakterijnykh Preparatov" Federal'Nogo Mediko-Biologicheskogo Agentstva Rossii Spbniivs Fmba Rossii)

METHOD FOR PREPARING HIGH-PURITY VIRION CONCENTRATE Russian patent published in 2014 - IPC A61K39/145 A61P31/16 C12N7/02

Abstract RU 2535153 C1

FIELD: medicine.

SUBSTANCE: chicken embryos are infected; a virus-containing allantoic fluid (VAF) is collected, and the VAF is purified by microfiltration. The VAF is purified with the use of polyethylene glycol of the molecular weight of 6000 in the concentration of 1.5% and microfiltered on depth filters having pore diameters of 1.0 mcm and 10.0 mcm. Further, the purified VAF is concentrated by ultrafiltration on membranes with the molecular weight cut 100 kD, and the prepared concentrate is purified in a sucrose gradient by ultracentrifugation.

EFFECT: using the method enables the higher quality of virion purification, as well as the higher number of viral antigens recovered from one chicken embryo.

1 tbl, 1 dwg, 6 ex

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RU 2 535 153 C1

Authors

Trukhin Viktor Pavlovich

Petrovskij Stanislav Viktorovich

Ivanova Natal'Ja Evgen'Evna

Lobzin Jurij Vladimirovich

Dates

2014-12-10—Published

2013-09-04—Filed