METHOD OF PRODUCING CERAMIC BASED ON OCTACALCIUM PHOSPHATE (OCP) Russian patent published in 2016 - IPC A61L27/12 A61K6/00 A61F2/28 C04B35/447 

FIELD: ceramic industry.

SUBSTANCE: group of inventions relates to production of ceramic materials for bone defects replacement in orthopaedics, dentistry, maxillofacial surgery, neurosurgery, oncology. Disclosed is a method of producing ceramic material of the following phase composition: 80-100 wt% of octacalcium phosphate, 0-10 wt% of hydroxyapatite, 0-10 wt% of α-tricalcium phosphate, involving the following steps: 1) transformation of ceramic material with the phase composition of 100 wt% α-tricalcium phosphate into dicalcium phosphate dihydrate in A solution and, with the weight ratio of α-tricalcium phosphate and A solution of 1:100 and the temperature of 35±1 °C; 2) transformation of the material obtained at the previous step into the final product in B solution with the weight ratio of material obtained at the previous step and B solution of 1:100 and the temperature of 35±1 °C. A solution used is in fact a buffer solution, which is the water solution of 1.5 M of sodium acetate and 0.15±0.02M of glutamic acid conditioned by orthophosphoric acid to the pH value of 5.5±0.1; B solution is a buffer solution, which is the water solution of 1.5 M of sodium acetate with the pH value of 8.7±0.1. Also disclosed is a ceramic material obtained with the use of the said method.

EFFECT: group of inventions enables to obtain ceramic materials (including granules, blocks, coatings for implants) based on OCP at physiological temperatures, while keeping dimensions and macrostructure of the initial ceramic material α-TCP.

12 cl, 1 tbl, 12 ex, 4 dwg