METHOD FOR MAKING MATRICES BASED ON LOW-TEMPERATURE MODIFICATIONS OF CALCIUM PHOSPHATES FOR BONE ENGINEERING Russian patent published in 2019 - IPC A61L27/12 A61F2/28 

FIELD: medicine.

SUBSTANCE: invention refers to medicine and concerns composite materials for plastic reconstruction of damaged bone tissues. Proposed method for making matrices based on low-temperature modifications of calcium phosphate (CP) for bone engineering involves 3 stages. At first step, article is shaped to required degree by layer filling of granules or powders α-tricalcium phosphate (α-TCP) into a mold, the parameters of which correspond to parameters of the end product, and impregnation of each layer until complete impregnation with a solution of the composition: 1.5M sodium acetate, 0.15M L-glutamic acid, orthophosphoric acid to pH 4.75, obtaining a bulk matrix of 5–20 wt. % dicalcium phosphate dihydrate (DCPD), 80–95 wt. % tricalcium phosphate (TCP). At the second stage, the volumetric matrix formed at the first stage is maintained in a buffer solution of the following composition: 1.5M sodium acetate, 0.15M L-glutamic acid, 0.035M calcium chloride, orthophosphoric acid to pH 5.5, at temperature of 35±2 °C, at a weight ratio of material to liquid of 1/100, respectively, for minimum of 168 hours to obtain a bulk matrix of 80–100 wt. % DCPD and 0–20 wt. % TCP. At the third stage, the three-dimensional matrix formed at the second step is held in a buffer solution of the following composition: 1.5M sodium acetate, 0.035M calcium chloride, under conditions of temperature 35±2 °C, at material to liquid weight ratio of 1/100 for at least 168 hours respectively to obtain a bulk matrix of 80–100 wt. % octacalcium phosphate (OCF) and 0–20 wt. % TCF.

EFFECT: technical result is the technology of creating volumetric products based on low-temperature modifications of FC for use in medicine when performing operations for replacement of bone tissue defects.

1 cl, 1 ex, 3 dwg