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(19)

(11)

2 683 514

(13)

(51)

IPC

C12N15/85(2006-01-01)

A01K67/27(2006-01-01)

(21) (22)

Application

2014140239, 2013-03-05

(24)

Start date

2013-03-05

(22)

Actual filing date

2013-03-05

(45)

Published

2019-03-28

(72)

Inventor

Babb RobertMcwhirter JohnMacdonald LynnStevens SeanDavis SamuelBuckler David R.Meagher Karolina A.Murphy Andrew J.

(73)

Holder

Regeneron Farmasyutikalz, Ink.

COMMON LIGHT CHAIN MOUSE Russian patent published in 2019 - IPC C12N15/85 A01K67/27

Abstract RU 2683514 C2

FIELD: biochemistry.

SUBSTANCE: invention relates to biochemistry, in particular to a genetically modified mouse for producing an antibody, wherein the antibody comprising a first immunoglobulin heavy chain, comprising a first human immunoglobulin heavy chain variable domain encoded by a human immunoglobulin heavy chain variable region comprising V_H2-26, V_H3-21, V_H3-64 or somatic hypermutations thereof. Use of said genetically modified mouse in the production of an antibody and in the production of a bispecific antibody is also disclosed. Invention also relates to a method for producing an antibody to an antigen of interest, wherein the antibody comprises an immunoglobulin heavy chain comprising a human immunoglobulin heavy chain variable domain encoded by the sequence of the human immunoglobulin heavy chain variable regions, comprising human V_H2-26, V_H3-21, V_H3-64 or somatic hypermutations thereof, as well as to a method for producing a fully human bispecific antibody.

EFFECT: invention allows efficiently producing an antibody in a genetically modified mouse.

24 cl, 6 dwg, 22 tbl, 12 ex

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RU 2 683 514 C2

Authors

Babb Robert

Mcwhirter John

Macdonald Lynn

Stevens Sean

Davis Samuel

Buckler David R.

Meagher Karolina A.

Murphy Andrew J.

Dates

2019-03-28—Published

2013-03-05—Filed