COMMON LIGHT CHAIN MOUSE Russian patent published in 2019 - IPC C12N15/85 A01K67/27 

Abstract RU 2683514 C2

FIELD: biochemistry.

SUBSTANCE: invention relates to biochemistry, in particular to a genetically modified mouse for producing an antibody, wherein the antibody comprising a first immunoglobulin heavy chain, comprising a first human immunoglobulin heavy chain variable domain encoded by a human immunoglobulin heavy chain variable region comprising VH2-26, VH3-21, VH3-64 or somatic hypermutations thereof. Use of said genetically modified mouse in the production of an antibody and in the production of a bispecific antibody is also disclosed. Invention also relates to a method for producing an antibody to an antigen of interest, wherein the antibody comprises an immunoglobulin heavy chain comprising a human immunoglobulin heavy chain variable domain encoded by the sequence of the human immunoglobulin heavy chain variable regions, comprising human VH2-26, VH3-21, VH3-64 or somatic hypermutations thereof, as well as to a method for producing a fully human bispecific antibody.

EFFECT: invention allows efficiently producing an antibody in a genetically modified mouse.

24 cl, 6 dwg, 22 tbl, 12 ex

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RU 2 683 514 C2

Authors

Babb Robert

Mcwhirter John

Macdonald Lynn

Stevens Sean

Davis Samuel

Buckler David R.

Meagher Karolina A.

Murphy Andrew J.

Dates

2019-03-28Published

2013-03-05Filed