MULTIORGANIC CHIP WITH IMPROVED DURABILITY AND HOMEOSTASIS Russian patent published in 2017 - IPC C12M3/00 C12M1/04 C12M1/34 

FIELD: biotechnology.

SUBSTANCE: multiorganic chip for organs and/or organoids cultivation is proposed. The chip contains consistently the base layer, the layer of organs, the organ retention layer, the antral layer and the actuator layer. The organ layer contains a plurality of separate organ equivalents, each organ equivalent contains one or more organ growth sections, each growth section comprises a cavity for organoid housing, a microinput and a microoutput for fluid connection of the cavity to an autonomous circulation system. The antral layer contains a plurality of cavities and tubes in fluid connection with the organ equivalents or organ growth sections. The organ retention layer isolates and/or stabilizes the organ layer to maintain fluid connection of the organ equivalents with the antral layer. The actuator layer contains a plurality of actuators to adjust the pressure force applied to the selected organ equivalent, autonomous circulation system and/or part thereof.

EFFECT: invention provides an imitation of the basic functions of the body necessary for an organ or body homeostasis.

15 cl, 9 dwg, 2 tbl, 2 ex