BACTERIAL VACCINE AND METHODS FOR PRODUCTION THEREOF Russian patent published in 2019 - IPC A61K39/112 A61K39/165 A61K31/715 C12N1/20 A61P31/04 A61P31/12 

FIELD: medicine.

SUBSTANCE: group of inventions concerns stable compositions of vaccines. Disclosed are: a vaccine for preventing typhoid caused by Salmonella typhi, comprising a partially de-O-acetylated capsular Vi-polysaccharide (ViPs) Salmonella typhi, conjugated with a carrier protein to form a conjugated vaccine antigen, wherein ViPs are derivatized with a line which is an adipic acid dihydrazide (ADH), or without it, wherein said antigen is present in concentration of 5 to 25 mcg per dose, preferably 25 mcg per dose; disclosed are methods for production thereof (embodiments), method for preventing typhoid fever and a combined composition of a vaccine containing an antigen which is a conjugate of Vi-polysaccharide S. typhi with tetanus toxin (ViPs-TT) and a measles antigen, where there is no antigenic interference between ViPs-TT and the measles antigen.

EFFECT: technical result: vaccines of the invention are capable of inducing the development of immunity against typhoid, including children under 2 years old by means of only one injection for the full course of vaccination.

15 cl, 13 dwg, 15 tbl