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(19)

(11)

2 614 859

(13)

(51)

IPC

A01K67/27(2006-01-01)

C07K16/18(2006-01-01)

(21) (22)

Application

2013152221, 2012-04-24

(24)

Start date

2012-04-24

(22)

Actual filing date

2012-04-24

(45)

Published

2017-03-29

(72)

Inventor

Mcwhirter JohnMacdonald LynnStevens SeanDavis SamuelBuckler David R.Hosiawa Karolina A.Murphy Andrew J.

(73)

Holder

Regeneron Pharmaceuticals, Inc.

ANIMALS DIFFERENT TO HUMAN ANIMAL EXPRESSING ANTIBODIES WITH COMMON LIGHT CHAIN Russian patent published in 2017 - IPC A01K67/27 C07K16/18

Abstract RU 2614859 C2

FIELD: biotechnology.

SUBSTANCE: genetically modified mouse is described. The mouse expresses a repertoire of immunoglobulin light chains, characterized by a limited number of light chain variable domains. Also mice are described that express only one or more variable domains of an immunoglobulin light chain from a limited repertoire in their germline. Methods for production of variable sections of the mouse light chain, including variable sections of human light chain, and methods for producction of human variable sections suitable for use in multispecific binding proteins, such as bispecific antibodies.

EFFECT: higher efficiency of compound application.

31 cl, 9 dwg, 14 tbl, 10 ex

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RU 2 614 859 C2

Authors

Mcwhirter John

Macdonald Lynn

Stevens Sean

Davis Samuel

Buckler David R.

Hosiawa Karolina A.

Murphy Andrew J.

Dates

2017-03-29—Published

2012-04-24—Filed