Show metadata Hide metadata

(19)

(11)

2 614 859

(13)

(51)

IPC

A01K67/27(2006-01-01)

C07K16/18(2006-01-01)

(21) (22)

Application

2013152221, 2012-04-24

(24)

Start date

2012-04-24

(22)

Actual filing date

2012-04-24

(45)

Published

2017-03-29

(72)

Inventor

Mcwhirter JohnMacdonald LynnStevens SeanDavis SamuelBuckler David R.Hosiawa Karolina A.Murphy Andrew J.

(73)

Holder

Regeneron Pharmaceuticals, Inc.

ANIMALS DIFFERENT TO HUMAN ANIMAL EXPRESSING ANTIBODIES WITH COMMON LIGHT CHAIN Russian patent published in 2017 - IPC A01K67/27 C07K16/18

Abstract RU 2614859 C2

FIELD: biotechnology.

SUBSTANCE: genetically modified mouse is described. The mouse expresses a repertoire of immunoglobulin light chains, characterized by a limited number of light chain variable domains. Also mice are described that express only one or more variable domains of an immunoglobulin light chain from a limited repertoire in their germline. Methods for production of variable sections of the mouse light chain, including variable sections of human light chain, and methods for producction of human variable sections suitable for use in multispecific binding proteins, such as bispecific antibodies.

EFFECT: higher efficiency of compound application.

31 cl, 9 dwg, 14 tbl, 10 ex

Similar patents RU2614859C2

Title	Year	Author	Number
COMMON LIGHT CHAIN MOUSE	2013	Babb Robert Mcwhirter John Macdonald Lynn Stevens Sean Davis Samuel Buckler David R. Meagher Karolina A. Murphy Andrew J.	RU2683514C2
MOUSE WITH COMMON LIGHT CHAIN	2011	Makuehrter Dzhon Makdonal'D Linn Stivens Shon Dehvis Sam'Juehl Bakler Dehvid R. Merfi Ehndrju Dzh.	RU2571205C2
COMMON LIGHT CHAIN MOUSE	2020	Makuerter, Dzhon Makdonald, Linn Stivens, Shon Devis, Samyuel Bakler, Devid R. Merfi, Endryu Dzh.	RU2826121C2
MICE EXPRESSING LIMITED IMMUNOGLOBULIN LIGHT CHAIN REPERTOIRE	2014	Babb Robert Mcwhirter John Macdonald Lynn Stevens Sean Davis Samuel Buckler David R. Meagher Karolina A. Murphy Andrew J.	RU2689664C2
MICE EXPRESSING LIMITED REPERTOIRE OF IMMUNOGLOBULIN LIGHT CHAINS	2014	Bebb, Robert Makvirter, Dzhon Makdonald, Linn Stivens, Shon Devis, Samyuel Bakler, Devid R. Meer, Karolina A. Merfi, Endryu Dzh.	RU2812814C2
MOUSE WITH COMMON LIGHT CHAIN	2011	Mcwhirtter John Macdonald Lynn Stevens Sean Davis Samuel Buckler David R. Murphy Andrew J.	RU2724663C2
HUMANISED UNIVERSAL LIGHT CHAIN MICE	2012	Makvirter Dzhon Makdonald Lin Stivens Shon Devis Semyuel Bakler Devid R. Khosiava Karolina A. Merfi Endryu Dzhej.	RU2664232C2
ANTIBODIES WITH BUILT IN THE LIGHT CIRCUIT BY HYSTIDINE AND GENETICALLY MODIFIED EXCELLENT FROM HUMAN ANIMALS FOR THEIR OBTAINING	2013	Mcwhirter John Macdonald Lynn Murphy Andrew J.	RU2644684C2
MICE WITH HUMANIZED UNIVERSAL LIGHT CHAIN	2012	Makvirter, Dzhon Makdonald, Lin Stivens, Shon Devis, Semyuel Bakler, Devid, R. Khosiava, Karolina, A. Merfi, Endryu, Dzhej	RU2787781C2
ANTIBODIES WITH HISTIDINE BUILT IN LIGHT CHAINS AND GENETICALLY MODIFIED ANIMALS DIFFERENT FROM HUMANS FOR THEIR PRODUCTION	2014	Mcwhirter John Macdonald Lynn Murphy Andrew J.	RU2694728C2

RU 2 614 859 C2

Authors

Mcwhirter John

Macdonald Lynn

Stevens Sean

Davis Samuel

Buckler David R.

Hosiawa Karolina A.

Murphy Andrew J.

Dates

2017-03-29—Published

2012-04-24—Filed