METHOD FOR EARLY PREDICTION OF ANTENATAL FETAL DEATH IN MONOCHORIONIC TWINS AFTER USING FETOSCOPIC LASER COAGULATION OF PLACENTAL ANASTOMOSES Russian patent published in 2019 - IPC G01N33/50 

FIELD: medicine.

SUBSTANCE: invention relates to the field of medicine, namely obstetrics and gynecology. In the venous blood of the pregnant determine the concentration of nitrogen nitrate (NO₃) by a spectrophotometric method based on enzymatic conversion of nitrate to nitrite involving nitrate reductase in a Griess reaction using test systems "R & D Systems" (USA). Content of placental growth factor (PLGF) and endoglin (sEnd) is determined using commercial test systems "Bender Medsystems" (Austria). Detection is carried out on immunoenzymometric analyzer "Wallac 1420 (Victor²)" by "PerkinElmer" (Finland). A prognostic index DI is calculated by formula DI = 1.197X₁ + 0.01X₂ – 0.204X₃ – 1.43X4 – 12.094, where X₁ is length of gestation, weeks, X₂ is concentration of PLGF, pg/ml, X₃ is total NO₃ concentration, mcmol/l, X₄ is concentration of endoglin, ng/ml. If DI < 0, a high risk of antenatal fetal death in monochorionic twins is predicted after using fetoscopic laser coagulation of placental anastomoses.

EFFECT: method provides more effective prediction of the risk of antenatal fetal death in monochorionic twins after using fetoscopic laser coagulation of placental anastomoses to 80.2 %.

1 cl, 3 ex