METHOD FOR INCREASING THE FREQUENCY OF FORMATION OF DOUBLE-STRAND BREAKS OF DNA IN HUMAN CELLS UNDER ACTION OF IONIZING RADIATIONS UNDER CONDITIONS OF RADIO MODIFIERS Russian patent published in 2019 - IPC A61K31/7068 A61K31/17 A61P35/00 

Abstract RU 2699670 C1

FIELD: medicine.

SUBSTANCE: invention relates to the field of medicine. Disclosed is a method for increasing the frequency of double-strand DNA stripping in human cells under the action of ionizing radiations in conditions of radio modifiers. As inhibitors of DNA repair before irradiation, a combination of formal preparations 1-β-D-arabinofuranosylcytosine and hydroxyurea.

EFFECT: invention provides higher effectiveness of radiation exposure on tumor cells and reduced local radiation dose.

1 cl, 3 dwg

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RU 2 699 670 C1

Authors

Krasavin Evgenij Aleksandrovich

Borejko Alla Vladimirovna

Kulikova Elena Anatolevna

Bulanova Tatyana Sergeevna

Timoshenko Gennadij Nikolaevich

Chausov Vladimir Nikolaevich

Dates

2019-09-09Published

2018-11-16Filed