METHOD FOR EVALUATING CHANGES IN CEREBRAL PERFUSION Russian patent published in 2019 - IPC A61B6/03 A61K51/00 A61P43/00 G06T7/60 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, particularly to radiation diagnostics, and can be used to assess changes in cerebral perfusion. A method for evaluating changes in cerebral perfusion involves single-photon emission computed tomography of the brain, constructing graphs of radiopharmaceutical accumulation by cerebral sections and perfusion analysis of cerebral tissue. Evaluation of the level of cell perfusion is carried out simultaneously on the area of the entire brain section, for this purpose, the analyzed section is placed into an image processing program, and a "lasso" type instrument is used to extract an image of the brain along the perimeter. Then, a tone curve is automatically arranged, which is transformed by dividing the image into right and left halves of the diagram with superposition of mirror projections on each other, thereby obtaining two separate images, each of which contains a straight and mirror projection of the diagram. Using the software, the obtained images are aligned so that the point of intersection of the diagonal lines is in the center of the image, while simultaneously reducing the transparency of the superimposed image by 50%. Final image with lower conditional triangle layer is stored for analysis. Preoperative and postoperative cerebral perfusion changes are evaluated by comparing the perfusion level diagram results in the selected cerebrum cut with the cell perfusion rate pattern for the corresponding brain section, wherein in the preoperative period, if the dense coloring area is higher than the norm boundary by the perfusion rate template and when the weak color area is shifted beyond the conditional triangle, the quantitative perfusion reduction is determined, if the area of dense and weak color within the limits of the standard perfusion pattern, perfusion is determined within the limits of standard values. In the postoperative period, if the area of dense coloring has increased relative to the norm by the perfusion rate template and the area of weak coloring has increased and shifted beyond the conditional triangle, then quantitative reduction of perfusion is determined, and if the area of dense coloring is within normal limits or is approximated to the norm by the perfusion pattern, if the weak color weak region is shifted to the area of the conditional triangle, and the area of weak coloring is within the norm or is approximated to the norm by the perfusion rate pattern, perfusion restoration is determined.

EFFECT: invention provides a graphical assessment of changes in regional cerebral blood flow to assess changes in cerebral perfusion on the area of the whole brain section, possibility of assessing the quality of perfusion irrespective of the method of imaging.

1 cl, 15 dwg, 3 ex