METHOD OF CORRECTING THROMBOSIS BY NICORANDIL IN AN ADMA-LIKE MODEL OF PREECLAMPSIA Russian patent published in 2020 - IPC A61M31/00 A61K31/452 A61P15/00 G09B23/28 

Abstract RU 2721291 C1

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to experimental pharmacology, and can be used for correction of thrombosis in ADMA-like model of preeclampsia. That is ensured by reproducing a model of experimental ADMA-like preeclampsia in Wistar rats. Thrombosis is corrected by oral administration of Nicorandil at dose of 10 mg/kg twice day from 14th to 20th day of pregnancy.

EFFECT: method provides marked thrombosis correction in a simulated pathology manifested by increased time of thrombosis.

1 cl, 1 tbl, 1 ex

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Authors

Gureev Vladimir Vladimirovich

Pokrovskij Mikhail Vladimirovich

Lokteva Tatyana Ivanovna

Antsiferova Oksana Evgenevna

Yurakova Alesya Viktorovna

Pokrovskaya Tatyana Grigorevna

Peresypkina Anna Aleksandrovna

Korokin Mikhail Viktorovich

Gudyrev Oleg Sergeevich

Pobeda Anna Sergeevna

Yakushev Vladimir Ivanovich

Korokina Liliya Viktorovna

Lazareva Galina Anatolevna

Gureeva Elena Gennadievna

Zhilinkova Lyudmila Anatolevna

Zatolokina Mariya Alekseevna

Shchurovskaya Kristina Vladimirovna

Kolesnichenko Pavel Dmitrievich

Pakhomov Sergej Petrovich

Severinova Olga Vladimirovna

Golubev Ivan Vladimirovich

Ivakhno Elena Nikolaevna

Povetka Elena Evgenevna

Gureeva Anastasiya Vladimirovna

Vajn Darya Sergeevna

Kudryavtsev Konstantin Viktorovich

Stupakova Elena Gennadievna

Dates

2020-05-18Published

2019-11-08Filed