Show metadata Hide metadata

(19)

(11)

2 735 765

(13)

(51)

IPC

G09B23/28(2006-01-01)

A61K31/44(2006-01-01)

(21) (22)

Application

2020117991, 2020-06-01

(24)

Start date

2020-06-01

(22)

Actual filing date

2020-06-01

(45)

Published

2020-11-06

(72)

Inventor

Gureev Vladimir VladmirovichPokrovskij Mikhail VladimirovichYurakova Alesya ViktorovnaGolubev Ivan VladimirovichPokrovskaya Tatyana GrigorevnaPeresypkina Anna AleksandrovnaKorokin Mikhail ViktorovichGudyrev Oleg SergeevichPobeda Anna SergeevnaYakushev Vladimir IvanovichKorokina Liliya ViktorovnaLazareva Galina AnatolevnaGureeva Elena GennadievnaChernomortseva Elena StanislavovnaKonovalova Elena AnatolevnaZatolokina Mariya AlekseevnaZhunusov Nikita Sergeevich

(73)

Holder

Federalnoe Gosudarstvennoe Avtonomnoe Obrazovatelnoe Uchrezhdenie Vysshego Obrazovaniya Gosudarstvennyj Natsionalnyj Issledovatelskij Universitet"

METHOD OF CORRECTING MORPHOLOGICAL CHANGES IN PLACENTA WITH SUBSTANCE OF 3-HYDROXY-2-ETHYL-6-METHYLPYRIDINIUM NICOTINATE IN ADMA-LIKE MODEL OF PREECLAMPSIA Russian patent published in 2020 - IPC G09B23/28 A61K31/44

Abstract RU 2735765 C1

FIELD: medicine.

SUBSTANCE: invention refers to medicine, particularly to experimental pharmacology, and can be used for correction of placental morphological disorders. A method of correcting morphological changes in the placenta in an ADMA-like model of preeclampsia involves reproducing a preeclampsia model in Wistar rats daily from 14th to 20th day of pregnancy by intraperitoneal introduction of L-nitro-arginine-methyl ether in dose of 25 mg/kg, wherein to correct the morphological changes in the placenta, intraperitoneal 3-hydroxy-2-ethyl-6-methylpyridinium nicotinate is administered in dosage 260 mg/kg from 14 to 20 days of pregnancy.

EFFECT: invention provides pronounced correction of placental morphological changes in conditions of reproduced ADMA-like model of preeclampsia.

1 cl, 1 ex, 1 tbl

Similar patents RU2735765C1

Title	Year	Author	Number
METHOD FOR CORRECTION OF PLACENTAL MICROCIRCULATION DISORDER WITH SUBSTANCE OF 3-HYDROXY-2-ETHYL-6-METHYLPYRIDINIUM NICOTINATE IN ADMA-LIKE MODEL OF PREECLAMPSIA	2020	Gureev Vladimir Vladimirovich Pokrovskij Mikhail Vladimirovich Yurakova Alesya Viktorovna Golubev Ivan Vladimirovich Pokrovskaya Tatyana Grigorevna Peresypkina Anna Aleksandrovna Korokin Mikhail Viktorovich Gudyrev Oleg Sergeevich Pobeda Anna Sergeevna Yakushev Vladimir Ivanovich Korokina Liliya Viktorovna Lazareva Galina Anatolevna Gureeva Elena Gennadievna Chernomortseva Elena Stanislavovna Konovalova Elena Anatolevna Zatolokina Mariya Alekseevna Zhunusov Nikita Sergeevich	RU2735766C1
METHOD FOR CORRECTING ENDOTHELIAL DYSFUNCTION WITH SUBSTANCE OF 3-HYDROXY-2-ETHYL-6-METHYLPYRIDINIUM NICOTINATE IN AN ADMA-LIKE MODEL OF PREECLAMPSIA	2020	Gureev Vladimir Vladimirovich Pokrovskij Mikhail Vladimirovich Yurakova Alesya Viktorovna Golubev Ivan Vladimirovich Pokrovskaya Tatyana Grigorevna Peresypkina Anna Aleksandrovna Korokin Mikhail Viktorovich Gudyrev Oleg Sergeevich Pobeda Anna Sergeevna Yakushev Vladimir Ivanovich Korokina Liliya Viktorovna Lazareva Galina Anatolevna Gureeva Elena Gennadievna Chernomortseva Elena Stanislavovna Konovalova Elena Anatolevna Zatolokina Mariya Alekseevna Zhunusov Nikita Sergeevich	RU2735903C1
METHOD OF CORRECTION OF STRUCTURAL DAMAGES IN PLACENTA WITH PEPTIDE IMITATING ALPHA-HELIX B ERYTHROPOIETIN IN ADMA-LIKE MODEL OF PREECLAMPSIA	2020	Gureev Vladimir Vladimirovich Golubev Ivan Vladimirovich Soldatov Vladislav Olegovich Pokrovskij Mikhail Vladimirovich Pokrovskaya Tatyana Grigorevna Peresypkina Anna Aleksandrovna Korokin Mikhail Viktorovich Gudyrev Oleg Sergeevich Zatolokina Mariya Alekseevna Pobeda Anna Sergeevna Yakushev Vladimir Ivanovich Korokina Liliya Viktorovna Lazareva Galina Anatolevna Gureeva Elena Gennadievna	RU2724402C1
METHOD OF CORRECTING THROMBOSIS WITH RESVERATROL IN AN ADMA-LIKE MODEL OF PREECLAMPSIA	2019	Gureev Vladimir Vladimirovich Pokrovskij Mikhail Vladimirovich Lokteva Tatyana Ivanovna Antsiferova Oksana Evgenevna Yurakova Alesya Viktorovna Pokrovskaya Tatyana Grigorevna Peresypkina Anna Aleksandrovna Korokin Mikhail Viktorovich Gudyrev Oleg Sergeevich Pobeda Anna Sergeevna Yakushev Vladimir Ivanovich Korokina Liliya Viktorovna Lazareva Galina Anatolevna Gureeva Elena Gennadievna Zhilinkova Lyudmila Anatolevna Zatolokina Mariya Alekseevna Shchurovskaya Kristina Vladimirovna Kolesnichenko Pavel Dmitrievich Pokhomov Sergej Petrovich Severinova Olga Vladimirovna Golubev Ivan Vladimirovich Ivakhno Elena Nikolaevna Povetka Elena Evgenevna Gureeva Anastasiya Vladimirovna Vajn Darya Sergeevna Kudryavtsev Konstantin Viktorovich Stupakova Elena Gennadievna	RU2722273C1
METHOD FOR PLACENTAL MICROCIRCULATION DISORDER CORRECTION IN ADMA-LIKE GESTOSIS MODELS IN EXPERIMENT	2010	Pokrovskij Mikhail Vladimirovich Gureev Vladimir Vladimirovich Barsuk Anna Aleksandrovna Proskurjakova Elena Vital'Evna Lazareva Galina Anatol'Evna Pokrovskaja Tat'Jana Grigor'Evna Poljanskaja Oksana Sergeevna Gureeva Elena Gennadievna Korokin Mikhail Viktorovich Gudyrev Oleg Sergeevich Belous Aleksandr Sergeevich Tsybul'Skij Igor' Valer'Evich Danilenko Ljudmila Mikhajlovna Kochkarov Vladimir Iskhakovich Novikov Oleg Olegovich	RU2432618C1
METHOD OF PLACENTAL MICROCIRCULATION CORRECTION BY PEPTIDE IMITATING B ERYTHROPOIETIN ALPHA-SPIRAL WITH ADMA-LIKE PRE-ECLAMPSIA MODEL	2020	Gureev Vladimir Vladimirovich Golubev Ivan Vladimirovich Soldatov Vladislav Olegovich Pokrovskij Mikhail Vladimirovich Pokrovskaya Tatyana Grigorevna Peresypkina Anna Aleksandrovna Korokin Mikhail Viktorovich Gdyrev Oleg Sergeevich Zatolokina Mariya Alekseevna Pobeda Anna Sergeevna Yakushev Vladimir Ivanovich Korokina Liliya Viktorovna Lazareva Galina Anatolevna Gureeva Elena Gennadievna	RU2731919C1
METHOD OF CORRECTION OF PLACENTAL MICROCIRCULATION DISORDERS WITH ADMA-LIKE MODEL OF PREECLAMPSIA	2018	Antsiferova Oksana Evgenevna Yurakova Alesya Viktorovna Lokteva Tatyana Ivanovna Gureev Vladimir Vladimirovich Pokrovskij Mikhail Vladimirovich Pokrovskaya Tatyana Grigorevna Peresypkina Anna Aleksandrovna Korokin Mikhail Viktorovich Gudyrev Oleg Sergeevich Pobeda Anna Sergeevna Yakushev Vladimir Ivanovich Korokina Liliya Viktorovna Lazareva Galina Anatolevna Gureeva Elena Gennadievna Zhilinkova Lyudmila Anatolevna Zotolokina Mariya Alekseevna Shchurovskaya Kristina Vladimirovna	RU2696196C1
METHOD OF CORRECTION OF PLACENTAL MICROCIRCULATION DISORDERS WITH 2-HYDROXYPHENYLTHIOACETAMIDE DERIVATIVES	2019	Gureev Vladimir Vladimirovich Pokrovskij Mikhail Vladimirovich Lokteva Tatyana Ivanovna Antsiferova Oksana Evgenevna Yurakova Alesya Viktorovna Pokrovskaya Tatyana Grigorevna Peresypkina Anna Aleksandrovna Korokin Mikhail Viktorovich Gudyrev Oleg Sergeevich Pobeda Anna Sergeevna Yakushev Vladimir Ivanovich Korokina Liliya Viktorovna Lazareva Galina Anatolevna Gureeva Elena Gennadievna Zhilinkova Lyudmila Anatolevna Zatolokina Mariya Alekseevna Shchurovskaya Kristina Vladimirovna Kolesnichenko Pavel Dmitrievich Pakhomov Sergej Petrovich Severinova Olga Vladimirovna Golubev Ivan Vladimirovich Ivakhno Elena Nikolaevna Povetka Elena Evgenevna Gureeva Anastasiya Vladimirovna Vajn Darya Sergeevna Kudryavtsev Konstantin Viktorovich	RU2721554C1
METHOD OF CORRECTION OF PLACENTAL MICROCIRCULATION DISORDERS WITH USING DETRALEX	2019	Gureev Vladimir Vladimirovich Pokrovskij Mikhail Vladimirovich Lokteva Tatyana Ivanovna Antsiferova Oksana Evgenevna Yurakova Alesya Viktorovna Pokrovskaya Tatyana Grigorevna Peresypkina Anna Aleksandrovna Korokin Mikhail Viktorovich Gudyrev Oleg Sergeevich Pobeda Anna Sergeevna Korokina Liliya Viktorovna Lazareva Galina Anatolevna Gureeva Elena Gennadievna Zhilinkova Lyudmila Anatolevna Zatolokina Mariya Alekseevna Shchurovskaya Kristina Vladimirovna Kolesnichenko Pavel Dmitrievich Pakhomov Sergej Petrovich Severinova Olga Vladimirovna Golubev Ivan Vladimirovich Ivakhno Elena Nikolaevna Povetka Elena Evgenevna Gureeva Anastasiya Vladimirovna Vajn Darya Sergeevna Kudryavtsev Konstantin Viktorovich Yakushev Vladimir Ivanovich	RU2727572C1
METHOD OF CORRECTION OF MICROCIRCULATION DISORDERS IN PLACENTA WITH CARBAMYLATED DARBEPOETIN IN ADMA-LIKE MODEL OF PREECLAMPSIA	2019	Gureev Vladimir Vladimirovich Pokrovskij Mikhail Vladimirovich Yurakova Alesya Viktorovna Antsiferova Oksana Evgenevna Lokteva Tatyana Ivanovna Pokrovskaya Tatyana Grigorevna Peresypkina Anna Aleksandrovna Korokin Mikhail Viktorovich Gudyrev Oleg Sergeevich Pobeda Anna Sergeevna Yakushev Vladimir Ivanovich Korokina Liliya Viktorovna Lazareva Galina Anatolevna Gureeva Elena Gennadievna Zhilinkova Lyudmila Anatolevna Zatolokina Mariya Alekseevna Shchurovskaya Kristina Vladimirovna Kolesnichenko Pavel Dmitrievich Pakhomov Sergej Petrovich Severinova Olga Vladimirovna Golubev Ivan Vladimirovich Ivakhno Elena Nikolaevna Povetka Elena Evgenevna Gureeva Anastasiya Vladimirovna Vajn Darya Sergeevna Zhuchenko Maksim Andreevich	RU2720103C1

RU 2 735 765 C1

Authors

Gureev Vladimir Vladmirovich

Pokrovskij Mikhail Vladimirovich

Yurakova Alesya Viktorovna

Golubev Ivan Vladimirovich

Pokrovskaya Tatyana Grigorevna

Peresypkina Anna Aleksandrovna

Korokin Mikhail Viktorovich

Gudyrev Oleg Sergeevich

Pobeda Anna Sergeevna

Yakushev Vladimir Ivanovich

Korokina Liliya Viktorovna

Lazareva Galina Anatolevna

Gureeva Elena Gennadievna

Chernomortseva Elena Stanislavovna

Konovalova Elena Anatolevna

Zatolokina Mariya Alekseevna

Zhunusov Nikita Sergeevich

Dates

2020-11-06—Published

2020-06-01—Filed