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2 722 273

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IPC

A61K31/00(2006-01-01)

A61K31/05(2006-01-01)

A61K38/12(2006-01-01)

A61P7/02(2006-01-01)

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Application

2019136338, 2019-11-12

(24)

Start date

2019-11-12

(22)

Actual filing date

2019-11-12

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Published

2020-05-28

(72)

Inventor

Gureev Vladimir VladimirovichPokrovskij Mikhail VladimirovichLokteva Tatyana IvanovnaAntsiferova Oksana EvgenevnaYurakova Alesya ViktorovnaPokrovskaya Tatyana GrigorevnaPeresypkina Anna AleksandrovnaKorokin Mikhail ViktorovichGudyrev Oleg SergeevichPobeda Anna SergeevnaYakushev Vladimir IvanovichKorokina Liliya ViktorovnaLazareva Galina AnatolevnaGureeva Elena GennadievnaZhilinkova Lyudmila AnatolevnaZatolokina Mariya AlekseevnaShchurovskaya Kristina VladimirovnaKolesnichenko Pavel DmitrievichPokhomov Sergej PetrovichSeverinova Olga VladimirovnaGolubev Ivan VladimirovichIvakhno Elena NikolaevnaPovetka Elena EvgenevnaGureeva Anastasiya VladimirovnaVajn Darya SergeevnaKudryavtsev Konstantin ViktorovichStupakova Elena Gennadievna

(73)

Holder

Federalnoe Gosudarstvennoe Avtonomnoe Obrazovatelnoe Uchrezhdenie Vysshego Obrazovaniya Gosudarstvennyj Natsionalnyj Issledovatelskij Universitet"

METHOD OF CORRECTING THROMBOSIS WITH RESVERATROL IN AN ADMA-LIKE MODEL OF PREECLAMPSIA Russian patent published in 2020 - IPC A61K31/00 A61K31/05 A61K38/12 A61P7/02

Abstract RU 2722273 C1

FIELD: medicine.

SUBSTANCE: invention relates to medicine, specifically to a method for correcting thrombosis in an ADMA-like model of preeclampsia, which involves reproducing an ADMA-like model of preeclampsia in Wistar rats daily from 14 to 20 of day of pregnancy by intraperitoneal introduction of L-nitro-arginine-methyl ester 25 mg/kg, characterized by that for correcting thrombosis orally administering resveratrol in dose of 2 mg/kg/day from 14 to 20 days of pregnancy.

EFFECT: invention provides an effective method of correcting thrombosis in an ADMA-like model of preeclampsia.

1 cl, 1 tbl

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RU 2 722 273 C1

Authors

Gureev Vladimir Vladimirovich

Pokrovskij Mikhail Vladimirovich

Lokteva Tatyana Ivanovna

Antsiferova Oksana Evgenevna

Yurakova Alesya Viktorovna

Pokrovskaya Tatyana Grigorevna

Peresypkina Anna Aleksandrovna

Korokin Mikhail Viktorovich

Gudyrev Oleg Sergeevich

Pobeda Anna Sergeevna

Yakushev Vladimir Ivanovich

Korokina Liliya Viktorovna

Lazareva Galina Anatolevna

Gureeva Elena Gennadievna

Zhilinkova Lyudmila Anatolevna

Zatolokina Mariya Alekseevna

Shchurovskaya Kristina Vladimirovna

Kolesnichenko Pavel Dmitrievich

Pokhomov Sergej Petrovich

Severinova Olga Vladimirovna

Golubev Ivan Vladimirovich

Ivakhno Elena Nikolaevna

Povetka Elena Evgenevna

Gureeva Anastasiya Vladimirovna

Vajn Darya Sergeevna

Kudryavtsev Konstantin Viktorovich

Stupakova Elena Gennadievna

Dates

2020-05-28—Published

2019-11-12—Filed