FIELD: medicine; biotechnology.
SUBSTANCE: invention refers to molecular biology and medicine. Disclosed is a method for prediction of the risk of developing diseases associated with the level of immunoglobulin E (IgE) in human blood serum. Polymorphisms rs2251746 and rs2427837 are investigated by allelic discrimination using TaqMan probes and primers. If the CT (rs2251746) allele combination with the GG allele (rs2427837) is detected, a high risk of the diseases associated with high serum IgE is predicted. When alleles are combined TT (rs2251746) and AG (rs2427837) or CT (rs2251746) and GG (rs2427837) – increased risk. When alleles are combined AG (rs2427837) and CT (rs2251746), or GG (rs2427837) and CC (rs2251746), or AA (rs2427837) and TT (rs2251746) – average risk. When alleles are combined AG (rs2427837) and CC (rs2251746) or AA (rs2427837) and CT (rs2251746) – reduced risk. When alleles are combined AA (rs2427837) and CC (rs2251746) – low risk.
EFFECT: invention provides enlarging the number of methods for prediction of development of IgE-dependent diseases.
1 cl, 2 dwg, 1 tbl, 3 ex
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