FIELD: medicine; gynecology.
SUBSTANCE: invention can be used for differentiating cervical neoplasms by lipid composition of tissue. For this purpose mass spectrometry is used to determine lipid profile of tissue using OPLS-DA method and using OPLS model, based on the following lipid levels: phosphatidylcholines (PC 32:0, PC 34:1, PC 36:4, PC 34:0, PC 38:4), ethanolamines (PE O-46:0, LPE 46:0, PE O-48:0, LPE 48:0, PE O-46:1) and sphingomyelins (SM 34:0, SM 42:2), estimated parameter (EP) is calculated by proposed formula. If EP<−0.5, tissue is considered to correspond to epithelium of UC with chronic cervicitis; at a value of −0.5<EP<0, the conclusion is made that tissue corresponds to epithelium of UC with LSIL; if value 0<EP<1, the tissue corresponds to the UC epithelium with HSIL; if EP>1, tissue is considered to correspond to cervical cancer epithelium.
EFFECT: method enables high-accuracy differentiation of different types of neoplastic process in epithelium of cervix uteri.
1 cl, 6 ex, 6 dwg
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR DIFFERENTIATION OF CERVICAL INTRAEPITHELIAL NEOPLASIAS BY ANALYZING THE PROTEOMIC COMPOSITION OF CERVICOVAGINAL FLUID | 2017 |
|
RU2674335C1 |
| METHOD FOR PREDICTING THE RISK OF PROGRESSION OF RECURRENT CERVICAL INTRAEPITHELIAL NEOPLASIAS OF LOW DEGREE OF ONCOGENIC RISK ASSOCIATED WITH HUMAN PAPILLOMAVIRUS INFECTION | 2020 |
|
RU2748719C1 |
| DIAGNOSTIC TECHNIQUE FOR HYPERPROLIFERATIVE CONDITIONS AND METHOD FOR ASSESSING RISK OF CERVICAL CANCER ACCOMPANYING CERVICAL INTRAEPITHELIAL NEOPLASIA AND PAPILLOMA VIRUS CARRIER STATE BY DETERMINIG MRNA OF FUNCTIONAL HUMAN GENE COMPLEX | 2012 |
|
RU2532344C2 |
| METHOD FOR ASSESSING THE RISK OF PROGRESSION OF INTRAEPITHELIAL CERVICAL NEOPLASIA AND DEVELOPMENT OF CERVICAL CANCER BY DETERMINING THE LEVELS OF HUMAN MRNA GENES | 2015 |
|
RU2660360C2 |
| METHOD OF CHOOSING TACTICS OF MANAGING PATIENTS WITH CERVICAL NEOPLASIA | 2011 |
|
RU2472424C1 |
| METHOD FOR PREDICTION OF PROGRESSION OF LOW-GRADE CERVICAL SQUAMOUS INTRAEPITHELIAL LESION WITH UNDERLYING HUMAN PAPILLOMAVIRUS INFECTION | 2021 |
|
RU2766719C1 |
| METHOD FOR PREDICTING THE RISK OF RECURRENCE IN HPV16-POSITIVE PATIENTS WITH SQUAMOUS INTRAEPITHELIAL HIGH-GRADE DISEASE ON THE BASIS OF DETERMINING THE PHYSICAL STATUS OF THE VIRUS | 2019 |
|
RU2719581C1 |
| METHOD FOR ASSESSING DEGREE OF MALIGNANCY OF INTRAEPITHELIAL INVOLVEMENT OF SQUAMOUS EPITHELIUM OF UTERUS | 2023 |
|
RU2818148C1 |
| METHOD FOR EARLY DIAGNOSTICS OF CERVICAL INTRAEPITHELIAL NEOPLASIAS (CIN) BASED ON METABOLIC MARKERS STUDY | 2016 |
|
RU2629632C1 |
| METHOD FOR PREVENTING PRECANCER RECURRENCE AND PRIMARY CERVICAL CANCER FOLLOWING ORGAN-PRESERVING TREATMENT BY DIAGNOSING AND TREATING HPV IN ANOGENITAL-OROPHARYNGEAL SPHERE IN SEXUAL PAIRS | 2020 |
|
RU2733934C2 |
