HUMANIZED RODENTS WHICH EXPRESS HEAVY CHAINS CONTAINING VDOMAINS Russian patent published in 2022 - IPC A01K67/27 C07K16/46

Abstract RU 2770016 C2

FIELD: biotechnology.

SUBSTANCE: invention relates to a method of producing an antibody which binds to an antigen of interest. Method comprises producing a mammalian cell engineered for antibody expression, which is specific for the antigen of interest, insertion of one or more human gene segments V_L and one or more human gene segments J_L and insertion of one or more human V_L gene segments and one or more human J_L gene segments and an ectopic nucleotide sequence which codes an ADAM6 protein or a functional fragment thereof.

EFFECT: invention is effective for producing antibodies applicable for producing therapeutic agents for humans.

19 cl, 9 dwg, 1 tbl, 4 ex

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RU 2 770 016 C2

Authors

Makdonald Linn

Gurer Sagan

Meagkher Karolina A.

Stivens Shon

Merfi Endryu Dzhej.

Dates

2022-04-14—Published

2013-02-01—Filed