FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology, namely to ophthalmic oncology, and is intended for determining the risk of transformation of a stationary choroidal nevus into a progressive nevus. Genomic ctDNA with mutations of the GNAQ/GNA11 genes is determined in peripheral blood plasma using polymerase chain reaction (PCR) in real time. If mutations are present in exons 4 and/or 5, the risk of transformation is determined.
EFFECT: provides a possibility to select an appropriate treatment strategy as a result of screening patients with a high risk of transformation of a stationary nevus into a progressive choroidal nevus.
1 cl, 1 tbl, 4 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR DIFFERENTIAL DIAGNOSIS OF DELIMITED CHOROIDAL HEMANGIOMA AND PIGMENT-FREE CHOROIDAL MELANOMA | 2021 |
|
RU2777346C1 |
| METHOD FOR DIFFERENTIAL DIAGNOSIS OF INITIAL CHOROID MELANOMA AND CHOROID NEVUS BY MEANS OF OPTICAL COHERENT TOMOGRAPHY WITH ANGIOGRAPHIC MODE | 2019 |
|
RU2705419C1 |
| METHOD FOR DIFFERENTIAL DIAGNOSIS OF PRIMARY MELANOMA AND CHOROID NEVUS | 2018 |
|
RU2689190C1 |
| METHOD OF DIFFERENTIAL DIAGNOSIS OF IRIS MELANOMA AND PROGRESSIVE IRIS NEVUS | 2023 |
|
RU2799919C1 |
| DIFFERENTIAL DIAGNOSTIC METHOD FOR DISTINGUISHING INITIAL CHOROID MELANOMA AND PROGRESSING CHOROID NEVUS OF PARAMACULAR LOCALIZATION | 2006 |
|
RU2303951C1 |
| METHOD FOR DIFFERENTIAL DIAGNOSIS OF PROGRESSIVE NEVUS AND CONJUNCTIVAL MELANOMA | 2022 |
|
RU2782134C1 |
| DIAGNOSTIC TECHNIQUE FOR ANGIOGRAPHICALLY AVASCULAR INITIAL CHOROID MELANOMA | 2010 |
|
RU2440070C1 |
| METHOD FOR DIAGNOSING CHOROIDAL MELANOMA | 2014 |
|
RU2582287C2 |
| METHOD FOR DETERMINING STAGES OF PIGMENT AND PIGMENTLESS PIGMENT RETINITIS | 2018 |
|
RU2707368C1 |
| METHOD OF DIAGNOSING INTRAOCULAR NEOPLASMS | 2008 |
|
RU2387378C1 |
