Show metadata Hide metadata

(19)

(11)

2 756 325

(13)

(51)

IPC

A61K31/433(2006-01-01)

A61P25/00(2006-01-01)

G09B23/28(2006-01-01)

(21) (22)

Application

2021108836, 2021-04-01

(24)

Start date

2021-04-01

(22)

Actual filing date

2021-04-01

(45)

Published

2021-09-29

(72)

Inventor

Martynova Olga ViktorovnaSkachilova Sofiya YakovlevnaCherevatenko Roman FedorovichGureev Vladimir VladimirovichAntsiferov Oleg VladimirovichPeresypkina Anna AleksandrovnaPokrovskij Mikhail VladimirovichProskurina Oksana VladimirovnaMartynov Mikhail AlekseevichSimakina Ekaterina AleksandrovnaShilova Elena VladimirovnaBelyaeva Veronika SergeevnaTsuverkalova Yuliya MikhajlovnaStepenko Yuliya VladimirovnaDuzenko Andrej VladimirovichGubarev Artem ValerevichGasymova Sevindzh KamranovnaTikhojvanova Anna AntonovnaRyabchikova Alina Alekseevna

(73)

Holder

Federalnoe Gosudarstvennoe Avtonomnoe Obrazovatelnoe Uchrezhdenie Vysshego Obrazovaniya Gosudarstvennyj Natsionalnyj Issledovatelskij Universitet"

METHOD FOR CORRECTING BEHAVIORAL STATUS OF 2-AMINO-5-ETHYL-1,3,4-THIODIAZOLIUM-N-ACETYL-AMINOETHANOATE IN TRAUMATIC BRAIN INJURY Russian patent published in 2021 - IPC A61K31/433 A61P25/00 G09B23/28

Abstract RU 2756325 C1

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to a method for correcting the behavioral status in traumatic brain injury, including modeling traumatic brain injury in rats by free fall of a load weighing 155 g from a height of 0.6 m, characterized in that for the correction of pathology, it is administered intragastrically through probe 2-amino-5-ethyl-1,3,4-thiodiazolium-N-acetyl-aminoethanoate at a dose of 50 mg/kg, once, 30 minutes before modeling the pathology.

EFFECT: invention provides correction of the behavioral status with new ethylthiadiazole derivatives 2-amino-5-ethyl-1,3,4-thiodiazolium-N-acetyl-aminoethanoate in traumatic brain injury - TBI, which has antioxidant and antihypoxic activity and blocks the activation of free radical processes, and also lipid peroxidation of cell membranes in acute disorders of regional and general circulation.

1 cl, 2 tbl, 1 ex

Similar patents RU2756325C1

Title	Year	Author	Number
METHOD FOR CORRECTING THE BEHAVIORAL STATUS OF 2-AMINO-5-ETHYL-1,3,4-THIODIAZOLIUM-N-ACETYL-AMINOETHANOATE IN CASE OF BRAIN DAMAGE	2021	Martynova Olga Viktorovna Skachilova Sofiya Yakovlevna Cherevatenko Roman Fedorovich Gureev Vladimir Vladimirovich Antsiferov Oleg Vladimirovich Peresypkina Anna Aleksandrovna Pokrovskij Mikhail Vladimirovich Proskurina Oksana Vladimirovna Martynov Mikhail Alekseevich Simakina Ekaterina Aleksandrovna Shilova Elena Vladimirovna Belyaeva Veronika Sergeevna Tsuverkalova Yuliya Mikhajlovna Stepenko Yuliya Vladimirovna Duzenko Andrej Vladimirovich Gubarev Artem Valerevich Gasymova Sevindzh Kamranovna Tikhojvanova Anna Antonovna Ryabchikova Alina Alekseevna	RU2763012C1
METHOD FOR CORRECTION OF PATHOLOGY OF 2-AMINO-5-ETHYL-1,3,4-THIODIAZOLIUM-N-ACETYL-AMINOETHANOATE IN TRAUMATIC BRAIN INJURY	2021	Martynova Olga Viktorovna Skachilova Sofiya Yakovlevna Cherevatenko Roman Fedorovich Gureev Vladimir Vladimirovich Antsiferov Oleg Vladimirovich Peresypkina Anna Aleksandrovna Pokrovskij Mikhail Vladimirovich Simakina Ekaterina Aleksandrovna Shilova Elena Vladimirovna Danilenko Lyudmila Mikhajlovna Trunov Konstantin Sergeevich Belyaeva Veronika Sergeevna Tsuverkalova Yuliya Mikhajlovna Stepenko Yuliya Vladimirovna Proskurina Oksana Vladimirovna Pokrovskij Vladimir Mikhajlovich Patrakhanov Evgenij Aleksandrovich Ekimova Natalya Viktorovna Myagkaya Arina Aleksandrovna Mostovykh Anna Alekseevna	RU2766785C1
METHOD FOR CORRECTING NEUROLOGICAL DEFICIENCY OF 2-AMINO-5-ETHYL-1,3,4-THIODIAZOLIUM-N-ACETYL-AMINOETHANOATE IN TRAUMATIC BRAIN INJURY	2021	Martynova Olga Viktorovna Sachilova Sofiya Yakovlevna Cherevatenko Roman Fedorovich Gureev Vladimir Vladimirovich Antsiferov Oleg Vladimirovich Peresypkina Anna Aleksandrovna Pokrovskij Mikhail Vladimirovich Simakina Ekaterina Aleksandrovna Shilova Elena Vladimirovna Danilenko Lyudmila Mikhajlovna Trunov Konstantin Sergeevich Belyaeva Veronika Sergeevna Tsuverkalova Yuliya Mikhajlovna Stepenko Yuliya Vladimirovna Proskurina Oksana Vladimirovna Pokrovskij Vladimir Mikhajlovich Patrakhanov Evgenij Aleksandrovich Ekimova Natalya Viktorovna Myagkaya Arina Aleksandrovna Mostovykh Anna Alekseevna	RU2758433C1
METHOD FOR PREVENTING CEREBRAL ISCHEMIA	2018	Martynova Olga Viktorovna Gureev Vladimir Vladimirovich Pokrovskij Mikhail Vladimirovich Martynov Mikhail Alekseevich Beskhmelnitsyna Evgeniya Aleksandrovna Kostina Darya Aleksandrovna Solgalova Anastasiya Sergeevna Timokhina Alena Sergeevna Pokrovskaya Tatyana Grigorevna Nechaeva Inna Nikolaevna Korotonozhkin Aleksej Viktorovich Skachilova Sofiya Yakovlevna Zheltukhin Nikolaj Konstantinovich Sadchikova Natalya Petrovna	RU2696203C1
METHOD FOR CORRECTING NEUROLOGICAL DEFICIT IN TRAUMATIC BRAIN INJURY	2021	Antsiferov Oleg Vladimirovich Korokin Mikhail Viktorovich Gureev Vladimir Vladimirovich Cherevatenko Roman Fedorovich Netrebenko Aleksandr Sergeevich Pokrovskij Mikhail Vladimirovich Pokrovskaya Tatyana Grigorevna Belyaeva Veronika Sergeevna Gudyrev Oleg Sergeevich Zatolokina Mariya Alekseevna Pokrovskij Vladimir Mikhajlovich Gureeva Anastasiya Vladimirova Patrakhanov Evgenij Aleksandrovich Nesterov Arkadij Vitalevich Nesterova Natalya Igorevna Martynova Olga Viktorovna Danilenko Lyudmila Mikhajlovna Trunov Konstantin Sergeevich Stepenko Yuliya Vladimirovna Tsuverkalova Yuliya Mikhajlovna	RU2758245C1
METHOD FOR CORRECTING MORPHOLOGICAL CHANGES IN TRAUMATIC BRAIN INJURY	2021	Antsiferov Oleg Viktorovich Korokin Mikhail Viktorovich Gureev Vladimir Vladimirovich Cherevatenko Roman Fedorovich Netrebenko Aleksandr Sergeevich Pokrovskij Mikhail Vladimirovich Pokrovskaya Tatyana Grigorevna Belyaeva Veronika Sergeevna Gudyrev Oleg Sergeevich Zatolokina Mariya Alekseevna Pokrovskij Vladimir Mikhajlovich Gureeva Anastasiya Vladimirovna Patrakhanov Evgenij Aleksandrovich Nesterov Arkadij Vitalevich Nesterova Natalya Igorevna Martynova Olga Viktorovna Danilenko Lyudmila Mikhajlovna Trunov Konstantin Sergeevich Stepenko Yuliya Vladimirovna Tsuverkalova Yuliya Mikhajlovna	RU2758545C1
METHOD FOR BRAIN CELL REGENERATION WITH RECOVERY OF ITS FUNCTIONS	2023	Markova Evgeniya Valerevna Savkin Ivan Vladimirovich Serenko Evgenij Vladimirovich Knyazheva Mariya Aleksandrovna Nekhoroshev Evgenij Vladislavovich Akopyan Anna Aleksandrovna Tikhonova Mariya Aleksandrovna Amstislavskaya Tamara Gennadevna	RU2816789C1
METHOD FOR CORRECTION OF CEREBRAL ISCHEMIA WITH RAPITALAM SUBSTANCE IN EXPERIMENTS	2019	Avdeeva Natalia Viktorovna Pokrovskii Mikhail Vladimirovich Korokin Mikhail Viktorovich Peresypkina Anna Aleksandrovna Pokrovskii Vladimir Mikhailovich	RU2711906C1
IN VIVO METHOD FOR DETERMINING BIOCOMPATIBILITY OF SCAFFOLDS FOR NEUROTRANSPLANTATION	2021	Novozhilova Mariia Olegovna Mishchenko Tatiana Aleksandrovna Vedunova Mariia Valerevna	RU2812608C2
METHOD FOR CORRECTING THE NEUROLOGICAL STATUS WITH 2-ETHYL-6-METHYL-3-HYDROXY PYRIDINIUM-N-ACETYLAMINOACETATE IN CASE OF BRAIN DAMAGE DUE TO INTRACEREBRAL HEMORRHAGE IN THE EXPERIMENT	2022	Shcheblykina Olesya Viktorovna Skachilova Sofiya Yakovlevna Pokrovskij Mikhail Vladimirovich Shcheblykin Dmitrij Valerevich Kolesnichenko Pavel Dmitrievich Efimenko Svetlana Vladimirovna Simakina Ekaterina Aleksandrovna Shilova Elena Vladimirovna Danilenko Anton Pavlovich Trunov Konstantin Sergeevich Danilenko Lyudmila Mikhajlovna Boeva Elizaveta Valerevna Cherednichenko Albina Vyacheslavovna Bolgov Anton Alekseevich	RU2786315C1

RU 2 756 325 C1

Authors

Martynova Olga Viktorovna

Skachilova Sofiya Yakovlevna

Cherevatenko Roman Fedorovich

Gureev Vladimir Vladimirovich

Antsiferov Oleg Vladimirovich

Peresypkina Anna Aleksandrovna

Pokrovskij Mikhail Vladimirovich

Proskurina Oksana Vladimirovna

Martynov Mikhail Alekseevich

Simakina Ekaterina Aleksandrovna

Shilova Elena Vladimirovna

Belyaeva Veronika Sergeevna

Tsuverkalova Yuliya Mikhajlovna

Stepenko Yuliya Vladimirovna

Duzenko Andrej Vladimirovich

Gubarev Artem Valerevich

Gasymova Sevindzh Kamranovna

Tikhojvanova Anna Antonovna

Ryabchikova Alina Alekseevna

Dates

2021-09-29—Published

2021-04-01—Filed