MOLECULAR COMPUTING DEVICE BASED ON ESSENTIALLY NON-COMPLEMENTARY SINGLE-STRANDED NUCLEIC ACIDS WITH LOW AFFINITY TO EACH OTHER (OPTIONS) Russian patent published in 2021 - IPC G06N3/12 C12N15/113 C12Q1/68 

FIELD: molecular computing.

SUBSTANCE: group of inventions relates to the field of molecular computing devices. A molecular computing device (options), a method for performing calculations using a device, a pharmaceutical formulation containing devices, as well as the use of a pharmaceutical formulation for regulating gene expression are proposed. The molecular computing device includes a set of single-stranded nucleic acids, wherein the numerical measure of input signals are measures related to input molecules, the numerical measure of output signals are measures related to output molecules, input signals are transformed into output signals as a result of interactions between input molecules and output molecules. In the first option, single-stranded nucleic acids have low affinity of interaction with each other. In the second option, the total concentration of each single-stranded nucleic acid exceeds a value of the dissociation constant of complexes formed by single-stranded nucleic acid and other single-stranded nucleic acids of a set of complexes by no more than 100,000 times. In the third option, interactions between single-stranded nucleic acids are reversible binding of not completely complementary between single-stranded nucleic acids, wherein such acids are used that for any two single-stranded nucleic acids, the length of the longest connected section of their mutual complementarity does not exceed 10 bases.

EFFECT: inventions provide fast calculation, solving a wide range of problems, as well as operating with oligonucleotides of various lengths.

49 cl, 2 tbl, 23 ex, 13 dwg