FIELD: biotechnology.
SUBSTANCE: invention relates to the field of biotechnology, in particular to modified guide RNA for controlled inactivation of CRISPR/Cas9 genome editing system, which is 42-link oligoribonucleotide containing a photo-separable linker, as well as to its production method.
EFFECT: invention is effective for specific inactivation of CRISPR/Cas9 genome editing system in a certain period of time at a certain place.
8 cl, 8 dwg, 4 ex
| Title | Year | Author | Number |
|---|---|---|---|
| CRISPR/CAS9 TYPE II GENOME EDITING SYSTEM AND ITS USE | 2022 |
|
RU2794774C1 |
| COMPOSITIONS AND METHODS WITH USE OF NUCLEIC ACIDS TARGETED AT NUCLEIC ACIDS | 2014 |
|
RU2662932C2 |
| RNA-GUIDED ENGINEERING OF HUMAN GENOME | 2013 |
|
RU2699523C2 |
| SYSTEM FOR INCREASING EFFICIENCY OF MAMMALIAN GENOME EDITING THROUGH HOMOLOGOUS REPAIR | 2022 |
|
RU2808045C1 |
| SYSTEM FOR ATTRACTING PROTEIN TO DNA BREAK SITE TO INCREASE EFFICIENCY OF MAMMALIAN GENOME EDITING | 2022 |
|
RU2808601C1 |
| GENOME EDITING TOOL BASED ON LIGD PROTEIN FROM THE BACTERIUM PSEUDOMONAS PUTIDA AND CAS9 COMPLEX | 2022 |
|
RU2797049C1 |
| NEW TRANSCRIPTION ACTIVATOR | 2019 |
|
RU2800921C2 |
| CAS-EXPRESSING MOUSE EMBRYONIC STEM CELLS, AND MICE AND THEIR USE | 2018 |
|
RU2782358C2 |
| NEW COMPACT TYPE II CAS9 NUCLEASE FROM ANOXYBACILLUS FLAVITHERMUS | 2020 |
|
RU2749307C1 |
| RNA-CONDUCTORS TO SUPPRESS THE REPLICATION OF HEPATITIS B VIRUS AND FOR THE ELIMINATION OF HEPATITIS B VIRUS FROM HOST CELL | 2017 |
|
RU2652899C1 |
