FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology. Described is a bioreactor for RNA transcription in vitro. Reactor for RNA transcription in vitro, designed to operate in an automated manner in conditions corresponding to GMP principles. In particular, said reactor for RNA transcription in vitro allows multiple use of DNA matrix for various reactions of RNA transcription in vitro. Disclosed is the use of the described bioreactor for RNA transcription in vitro. Disclosed is a method of RNA transcription in vitro. Described is a module for transcription of DNA into RNA, as well as an automated device for producing RNA, containing the described bioreactor. Apparatus for producing RNA comprises (a) a module for synthesis of a DNA matrix, (b) a module for transcribing DNA into RNA, comprising said reactor for transcribing RNA in vitro, and optionally (c) a module for generating RNA.
EFFECT: invention extends the range of means for RNA transcription.
75 cl, 20 dwg, 1 ex
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