METHOD FOR PRODUCTION OF FILLER BASED ON HYALURONIC ACID, USING SPECIFIC CROSS-LINKING AGENTS Russian patent published in 2022 - IPC A61K8/73 A61K31/728 A61K47/36 A61Q19/08 A61L27/52 C08J3/75 

FIELD: chemistry.

SUBSTANCE: present invention relates to a method for the production of a lattice of hyaluronic acid hydrogel. This method includes following stages: mixing in a reactor equipped with a mixer of water, hyaluronic acid, a cross-linking agent selected from polyethylene glycol grade, a solution of alkali metal hydroxide; separation of the mixture into n parts, and transfer of the specified parts to n containers, where the mixture is subjected to ultrasound treatment; placement of n containers including the specified parts of the mixture in a thermostat from 4 to 8 hours to finish cross-linking of hyaluronic acid and promote the formation of gel of cross-linked hyaluronic acid. A number n of parts and containers is from 4 to 32.

EFFECT: obtaining a hyaluronic acid lattice with a lower swelling level compared to the previous state of the art.

10 cl