MICROFLUID DEVICE FOR SELECTIVE CAPTURE OF BIOLOGICAL OBJECTS Russian patent published in 2023 - IPC B01L3/00 G01N33/543 B81B1/00 B81B7/04 

FIELD: microfluid devices.

SUBSTANCE: microfluid device for selective capture of target biological objects is disclosed, containing a) an array of symmetrical columns in the form of a drop (1), in which chord lines (5) of symmetrical columns in the form of a drop are parallel to each other, while geometrical centers of symmetrical columns in the form of a drop form rhomboid lattice (4) characterized by that length (d) of a rhomb side in the lattice is formed as Euclidian distance between geometrical centers of two neighboring symmetrical columns in the form of a drop, b) twisting microfluid channel (2), and c) capture volume (3). In this case, twisting microfluid channel (2) contains a sequence of ellipse segments (13), each of which is characterized by a chord parallel to a large or small ellipse axis, wherein the specified chord is separated into inlet section (17) and outlet section (18), through which a target biological object enters ellipse segment (13) and leaves it, wherein ellipse segments are connected to each other, wherein the following ellipse segment is formed by rotation of the previous ellipse segment around its chord and parallel transfer to a distance equal to inlet section (17), along the chord, wherein capture volume (3) is determined by logic subtraction of the array of symmetrical columns in the form of a drop from the twisting microfluid channel.

EFFECT: invention provides an increase in the probability of object/surface interaction for capture of target biological objects among different other objects in a suspension, which leads to an increase in the efficiency of capture.

6 cl, 9 dwg