COMPOUND USED AS INHIBITOR OF BROMO-DOMAIN-CONTAINING PROTEINS, AND COMPOSITION Russian patent published in 2024 - IPC C07D471/04 C07D519/00 C07D487/04 A61K31/437 A61K31/4985 A61P35/00 

FIELD: pharmaceutics.

SUBSTANCE: invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof, where R₁ is independently selected from C_1-6 alkyl, where C_1-6 alkyl is optionally substituted with C₆ aryl or C_5-6 heteroaryl; where C_5-6 heteroaryl contains 1 or 2 heteroatoms independently selected from nitrogen or sulfur; R₂ is independently selected from H or C_1-6 alkyl; Q is -CH₂-or -NH-, where -CH₂- is optionally substituted with C_1-6 alkyl; X is C₆ aryl, where C₆ aryl is optionally substituted with halogen, halogen-C_1-6 alkyl, C_1-6 alkyl, C_1-6 alkoxy, C_1-6 alkylthio, C_1-6 alkoxycarbonyl or C_1-6 alkyl-SO₂-; where Y is Invention also relates to the crystalline form of 6-methyl-4-(2-methyl-1-(4-(trifluoromethyl)benzyl)-1H-imidazo[4,5-b]pyrazin-6-yl)-1H-pyrrolo [2,3-c]pyridin-7(6H)-one, pharmaceutical composition as bromodomain-containing protein 4 (BRD4) inhibitor based on said compounds.

EFFECT: novel compounds which can be used in medicine for treating BET-mediated diseases, such as cancer, are obtained.

22 cl, 3 dwg, 9 tbl, 70 ex