METHOD FOR STUDYING DYNAMICS OF BLV-INFECTION IN VIVO Russian patent published in 2024 - IPC G09B23/28 

FIELD: biotechnology.

SUBSTANCE: invention can be used to analyze the dynamics of BLV infection in laboratory rats, including when studying prevention and inhibition of malignant processes. Invention is a method for studying the dynamics of BLV infection in vivo, involving reproduction of BLV infection in laboratory rats according to the method described in the patent RU No. 2019110652 from 10.04.2019, with subsequent analysis of blood of experimental animals every three months by method of Real-Time PCR (PCR) for dynamics of proviral load and by method of ELISA (ELISA) for dynamics of antibody formation four times during a year, at that, positive dynamics of proviral load and/or antibody formation testifies to development of productive BLV-infection in animals, and the negative dynamics of the proviral load and antibody formation is considered to be inhibition of the BLV-induced malignant process.

EFFECT: proposed method for studying the dynamics of BLV infection in vivo provides high-reliability tracking of the intensity of the immune response of an infected organism with underlying proviral expansion and is available in design, characterized by high information content and efficiency of method for studying dynamics of BL F-infection in laboratory rats, which enables to recommend the developed method for studying the issues of preventing and inhibiting malignant processes.

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