FIELD: organic and medical chemistry.
SUBSTANCE: invention relates to substituted 5-oxo-5,6-dihydro-4H-1,3,4-thiadiazin-6-ylucetic acids of general formula I, which can be used as an antihyperglycemic agent. In formula I R=2-MePh (Ia—2-(5-oxo-2-phenyl-4-(o-tolyl)-5,6-dihydro-4H-1,3,4-thiadiazin-6-yl)acetic acid), R=Bn (Ib—2-(4-benzyl-5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-thiadiazin-6-yl)acetic acid). Invention also relates to a method for production thereof and an antihyperglycemic agent based thereon.
EFFECT: substituted 5-oxo-5,6-dihydro-4n-1,3,4-thiadiazin-6-yl-acetic acids, a method for production thereof and antihyperglycemic agents based thereon are disclosed.
3 cl, 2 tbl, 4 ex
| Title | Year | Author | Number |
|---|---|---|---|
| ANTIHYPERGLYCEMIC AGENT | 2023 |
|
RU2825134C1 |
| 4 - ((2-ARYL-2,4-DIHYDROXY-5-OXO-3-(3-OXO-3,4-DIHYDROQUINOXALIN-2-YL)-2,5-DIHYDRO-1N-PYRROL-1-YL)AMINO)BENZOIC ACIDS HAVING ANALGESIC ACTIVITY | 2019 |
|
RU2731215C1 |
| 2-CYCLOALKYLAMINO-5-THIENYL-1,3,4-THIADIAZINES, HYDROBROMIDES, WITH ANTIAGGREGANT ACTIVITY | 2008 |
|
RU2379306C1 |
| 5-(4'-HYDROXYPHENYL)-AND 5-(2',5'-DIHYDROXYPHENYL)-6 H-1,3,4-THIADIAZINE-2-AMINES, HYDROHALOGENIDES INHIBITING THROMBOCYTE AGGREGATION IN INTRAVENOUS INTRODUCTION | 2009 |
|
RU2458060C2 |
| 6,6-DIMETHYL-8-OXO-5,6,8,9-TETRAHYDROBENZO[F]-PYRROLO[2,1-ALPHA]ISOQUINOLINE-9-SPIRO-2-(3-AROYL-4-HYDROXY-1-O-HYDROXYPHENYL-5-OXO-2,5-DIHYDRO-1H-PYRROLES) AND 6,6-DIMETHYL-8-OXO-5,6,8,9-TETRAHYDROBENZO[F]PYRROLO[2,1-ALPHA]ISOQUINOLINE-9-SPIRO-2-(3-BENZOYL-4-HYDROXY-1-O-HYDROXYPHENYL-5-OXO-2,5-DIHYDRIO-1H-PYRROLE) ELICITING ANALGESIC ACTIVITY AND METHOD FOR THEIR PREPARING | 2006 |
|
RU2316557C1 |
| SUBSTITUTED 2-[(1Z)-1-(3,5-DIARYL-1,3,4-THIADIAZOL-2(3H)-YLIDEN)METHYL]-3,5-DIARYL-1,3,4-THIADIAZOL-3-IUM CHLORIDES AND METHOD OF OBTAINING THEREOF | 2014 |
|
RU2571102C1 |
| PATHOGENIC BACTERIA-INHIBITING BIOLOGICALLY ACTIVE SUBSTANCES AND METHOD OF INHIBITING PATHOGENIC BACTERIA TYPE III SECRETION | 2010 |
|
RU2447066C2 |
| 2-PIPERIDINO-5-(THIENYL-2)- AND 2-PIPERIDINO-5-(THIENYL-3)- 6H-1,3,4-THIADIAZINES HYDROBROMIDES POSSESSING ANTIAGGREGANT ACTION | 2010 |
|
RU2445310C2 |
| BIOLOGICALLY ACTIVE SUBSTANCES SUPPRESSING PATHOGENIC BACTERIA, AND METHOD FOR INHIBITING TYPE III SECRETION IN PATHOGENIC BACTERIA | 2012 |
|
RU2495036C1 |
| 2-ARYL-2,4-DIHYDROXY-2,5-DIHYDRO-3-HETERYL-5-OXO-1H-PYRROL-1-YL-4-METHYL BENZENESULPHANOLAMIDES WITH ANALGESIC ACTIVITY | 2015 |
|
RU2626650C2 |
