METHOD OF PRODUCING 2-(5-OXO-2,4-DIPHENYL-5,6-DIHYDRO-4H-1,3,4-THIADIAZIN-6-YL)ACETIC ACID Russian patent published in 2024 - IPC C07D285/16 A61K31/549 C07B41/00 

Abstract RU 2831020 C1

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing a compound of general formula I, where R=Ph. Disclosed method is carried out by reacting N'-phenylbenzothiohydrazide with maleic anhydride in catalysis with 1,4-diazabicyclo[2.2.2]octane in molar ratio 2.1:4.1:0.8, respectively, in ethyl acetate for 24 hours at ambient temperature, the end product is separated from ethyl acetate, for which ethyl acetate is distilled off, 2 parts of chloroform and 5 parts of hexane are successively added to the residue, the obtained precipitate of the end product is filtered and dried.

EFFECT: obtaining a compound with high output, which can be used in medicine, for example, as an antihyperglycemic agent.

1 cl, 1 tbl, 2 ex

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RU 2 831 020 C1

Authors

Trukhanova Yuliya Aleksandrovna

Yuskovets Valerij Nikolaevich

Kovanskov Vladislav Evgenevich

Ivkin Dmitrij Yurevich

Chernov Nikita Maksimovich

Kuvaeva Elena Vladimirovna

Ksenofontova Galina Vladimirovna

Yakovlev Igor Pavlovich

Dates

2024-11-28Published

2023-12-20Filed