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Application

97119126/13, 1997-11-24

(22)

Actual filing date

1997-11-24

(45)

Published

1999-08-20

(72)

Inventor

Mikhalishin V.V.Lezova T.N.Ulupov N.A.Gusev A.A.Zakharov V.M.

(73)

Holder

Vserossijskij Nauchno-Issledovatel'Skij Institut Zashchity Zhivotnykh

METHOD OF PREPARING INACTIVATED VACCINE AGAINST RABIES IN ANIMALS Russian patent published in 1999 - IPC

Abstract RU 2134590 C1

FIELD: veterinary science. SUBSTANCE: invention relates to preparing agents for specific rabies prophylaxis in all species of agricultural and domestic animals. Fixed rabies virus is cultured in suspension culture of cells VNK-21 at 35-37 C for 96-144 h. After termination of virus reproduction polyacrylic acid or feracryl (stabilizing agents) up to concentration 0.7-1.0% are added in virus-containing suspension followed by addition of ethyleneimine dimer (inactivating agent) up to concentration 0.1-0.3%. Mixture is incubated at 35-37 C for 20-24 h and obtained vaccine is used both as a liquid and dried form. To obtain the dried preparation a liquid vaccine is dried by sublimation. EFFECT: increased specific safety, immunogenic activity, stability and harmlessness of vaccine, decreased reactivity and allergenicity. 8 cl, 2 tbl, 5 ex

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RU 2 134 590 C1

Authors

Mikhalishin V.V.

Lezova T.N.

Ulupov N.A.

Gusev A.A.

Zakharov V.M.

Dates

1999-08-20—Published

1997-11-24—Filed

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