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2 279 290

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IPC

A61K39/00(2006-01-01)

G01N33/573(2006-01-01)

(21) (22)

Application

2004130389/13, 2004-10-19

(24)

Start date

2004-10-19

(22)

Actual filing date

2004-10-19

(45)

Published

2006-07-10

(72)

Inventor

Markov Viktor IvanovichKovtun Anatolij LeonidovichMakhlaj Aleksandr AleksandrovichMerkulov Vadim Anatol'EvichKarpov Vadim L'Vovich

(73)

Holder

Virusologicheskij Tsentr Nii Mikrobiologii Ministerstva Oborony Rossijskoj Federatsii

METHOD FOR PRODUCTION OF IMMUNOGENIC PREPARATIONS USING PROTEASOME SYSTEM USEFUL IN SCREENING OF AGENTS FOR VIRAL INFECTION PROPHYLAXIS Russian patent published in 2006 - IPC A61K39/00 G01N33/573

Abstract RU 2279290 C2

FIELD: molecular biology and virology.

SUBSTANCE: invention relates to method for production of immunogenic preparation of Venezuelan equine encephalomyelitis (VEE) virus by using proteasome system. Claimed method includes providing recombinant peptides ODC-E2-L, ODC-E2-M, and ODC-E2-N by isolation thereof from culture E.coli BL-21 (DE3). Further hydrolysis of recombinant peptides is carried out on substrate of activated 26S proteasomes. As a result purified immunogenic virus-specific peptides ODC-E2-L-gyd, ODC-E2-M-gyd, and ODC-E2-N-gyd are obtained.

EFFECT: method for design of new protective drugs against VEE.

3 dwg, 3 tbl

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RU 2 279 290 C2

Authors

Markov Viktor Ivanovich

Kovtun Anatolij Leonidovich

Makhlaj Aleksandr Aleksandrovich

Merkulov Vadim Anatol'Evich

Karpov Vadim L'Vovich

Dates

2006-07-10—Published

2004-10-19—Filed