INTEGRATIVE GENETIC CONSTRUCTION pWpr-le Russian patent published in 2015 - IPC C12N15/63 C12N15/16

Abstract RU 2539768 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to field of biotechnology, in particular to integrative genetic construction pWpr-le. Claimed invention can be used for introduction of gene of human/swine growth hormone releasing factor into chromosome of cell of Bacillus subtilis and related species of genus Bacillus and its further expression in said cells. Integrative genetic construction pWpr-le is characterised by nucleotide sequence, given in Fig. 2.

EFFECT: claimed invention makes it possible to obtain vector system for expression of gene of GHRH_le peptide in bacteria, possessing high stability in obtaining bacterial preparation of probiotic purpose in industrial conditions.

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RU 2 539 768 C2

Authors

Ehpova Elena Jur'Evna

Plaksina Antonina Georgievna

Shevelev Aleksej Borisovich

Dates

2015-01-27—Published

2012-02-17—Filed