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(19)

(11)

2 571 205

(13)

(51)

IPC

A01K67/27(2006-01-01)

C12N15/09(2006-01-01)

C12Q1/00(2006-01-01)

(21) (22)

Application

2012138431/10, 2011-02-08

(24)

Start date

2011-02-08

(22)

Actual filing date

2011-02-08

(45)

Published

2015-12-20

(72)

Inventor

Makuehrter DzhonMakdonal'D LinnStivens ShonDehvis Sam'JuehlBakler Dehvid R.Merfi Ehndrju Dzh.

(73)

Holder

Ridzheneron Farmas'Jutikalz, Ink.

MOUSE WITH COMMON LIGHT CHAIN Russian patent published in 2015 - IPC A01K67/27 C12N15/09 C12Q1/00

Abstract RU 2571205 C2

FIELD: medicine.

SUBSTANCE: invention relates to field of biotechnology and genetic engineering. described is genetically modified mouse, where mouse is not capable of regrouping and expression of endogenous sequence of variable region of murine immunoglobulin light chain. Mouse expresses only one or two variable domains of human light chains, coded by sequences of human immunoglobulins, functionally bound with gene of mouse constant kappa (K) region in mouse K endogenous locus. Mouse also expresses reverse chimeric antibody with light chain variable domain, obtained only from one or two gene segments of variable regions of human light chains, and mouse K constant domain and with variable domain of human heavy chain and constant domain of murine heavy chain from endogenous locus of murine heavy chain.

EFFECT: claimed invention can be used for selection of variable human regions in obtaining biospecific antibodies.

21 cl, 3 dwg, 12 tbl, 10 ex

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RU 2 571 205 C2

Authors

Makuehrter Dzhon

Makdonal'D Linn

Stivens Shon

Dehvis Sam'Juehl

Bakler Dehvid R.

Merfi Ehndrju Dzh.

Dates

2015-12-20—Published

2011-02-08—Filed