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(19)

(11)

2 826 121

(13)

(51)

IPC

A01K67/27(2006-01-01)

C12N15/09(2006-01-01)

C12N15/85(2006-01-01)

(21) (22)

Application

2020115682, 2020-05-12

(24)

Start date

2011-02-08

(22)

Actual filing date

2020-05-12

(45)

Published

2024-09-04

(72)

Inventor

Makuerter, DzhonMakdonald, LinnStivens, ShonDevis, SamyuelBakler, Devid R.Merfi, Endryu Dzh.

(73)

Holder

Ridzheneron Farmasyutikalz, Ink.

COMMON LIGHT CHAIN MOUSE Russian patent published in 2024 - IPC A01K67/27 C12N15/09 C12N15/85

Abstract RU 2826121 C2

FIELD: biotechnology.

SUBSTANCE: invention relates to an embryonic stem (ES) cell of a mouse genetically modified to contain a single rearranged sequence Vκ1-39/J person or single rearranged sequence Vκ3-20/J of a human being functionally linked to a mouse constant region κ, and a plurality of human immunoglobulin heavy chain variable region gene segments functionally linked to an endogenous mouse immunoglobulin heavy chain constant region, as well as to a method for production thereof. Also disclosed is a mouse embryo obtained from a mouse ES cell.

EFFECT: invention is effective for producing genetically modified mice.

32 cl, 3 dwg, 12 tbl, 10 ex

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RU 2 826 121 C2

Authors

Makuerter, Dzhon

Makdonald, Linn

Stivens, Shon

Devis, Samyuel

Bakler, Devid R.

Merfi, Endryu Dzh.

Dates

2024-09-04—Published

2020-05-12—Filed