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(19)

(11)

2 724 663

(13)

(51)

IPC

A01K67/27(2006-01-01)

C12N15/09(2006-01-01)

C12N15/85(2006-01-01)

(21) (22)

Application

2015147726, 2011-02-08

(24)

Start date

2011-02-08

(22)

Actual filing date

2011-02-08

(45)

Published

2020-06-25

(72)

Inventor

Mcwhirtter JohnMacdonald LynnStevens SeanDavis SamuelBuckler David R.Murphy Andrew J.

(73)

Holder

Ridzheneron Farmasyutikalz, Ink.

MOUSE WITH COMMON LIGHT CHAIN Russian patent published in 2020 - IPC A01K67/27 C12N15/09 C12N15/85

Abstract RU 2724663 C2

FIELD: biochemistry.

SUBSTANCE: invention relates to a genetically modified mouse, which expresses human immunoglobulin heavy and light chain variable domains, where human variable light chain variable domains are expressed from a single rearranged Vκ1-39/Jκ5 human sequence present in mouse germline genome, as well as to B-cell obtained from said mouse, and hybridoma obtained from said cell. Also disclosed is a method of producing an antibody and a method of producing a bispecific human antibody, which involve use of said mouse. Invention also relates to use of said mouse in producing an antibody, for cell production, which expresses a human bispecific antibody, as well as for identifying a variable domain of a human immunoglobulin heavy chain present in the immunoglobulin heavy chain, which is associated with common light chain.

EFFECT: invention enables efficient antibody production.

19 cl, 3 dwg, 12 tbl, 10 ex

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RU 2 724 663 C2

Authors

Mcwhirtter John

Macdonald Lynn

Stevens Sean

Davis Samuel

Buckler David R.

Murphy Andrew J.

Dates

2020-06-25—Published

2011-02-08—Filed